5 Written questions
5 Matching questions
- The undifferentiated and actively dividing cells occupy the entire epithelium
- It binds guanine residues in DNA. It generates DNA adducts
- 1. Accumulating mutations that disable the checkpoint system that monitors the length of
2. Acquiring mutations that maintain or activate telomerase activity
3. Acquiring an alternate mechanism to maintain chromosome ends even in the absence
of telomerase activity
- Mutations that inactivate cell cycle checkpoints
- a Cancer cells avoid replicative cell senscence by what three methods?
Why is panel C considered a high-grade neoplasia?
- c Continued cell division with unrepaired and/or missegregated DNA is due to the acquisition of what? That inactivate what?
- d P450 mediated aflatoxin modification generates a compound that binds what? Generating what?
- e What process makes a 'tumor' a 'cancer'?
5 Multiple choice questions
- What two cancers have been linked to increased tobacco use?
- Adducts formed by P450 mediated aflatoxin induce DNA strand breaks and block RNA polymerase progression thereby reducing what?
- What is a benign cancer of the epithelial cell with a glandular organization?
- The transport of tumor cells through the tissues and into the circulatory system is a difficult step as the cell must cross what two layers?
- In fibroblast cells, cellular division stops after how many divisions?
5 True/False questions
1. Cells that make up the supporting connective tissue (fibroblast cells)
2. Inflammatory white blood cells, and
3. Vascular epithelial cells → Tumorigenesis requires the assistance of other cell types. What are they?
Damage which accelerates the accumulation of DNA damage → All leukemic cells from a single patient have what?
An irreducible background incidence of cancer → The inherent limitations on the accuracy of DNA replication and repair will generate what?
Malignant → What is an invasive tumor; cancer?
Tumor initiator → Replicative cell senescence is controlled by what, an enzyme required for the maintenance of the repeative ends of