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____ is one of the major determinates of how a cell will die (membrane integrity, ATP levels, pro-apoptotic proteins)
mitochondrial protein released during cell singling events (if atp is present, will form with another protein to recruit caspase-9 and activate it. caspase-9 will activate other caspases)
if mitochondrial function is lost than ATP levels decline (<30%). if atp decreases enough Na+/K+ ATPase will not work, Na+ enters the cell along with water and Ca2+ = cell swelling
initiator, executioner (downstream), cytokine processors
caspases 15 different members divided into 3 groups:
executioner caspases, intrinsic, extrinsic
initiator caspases activates ______ ______; two processes:
p53, cell growth, cell death, cell cycle
tumor supressor protein that mediates several cellular processes:
mutated in over 50% of human cancers, loss of ____ is believed to be a key event in carcinogenesis in prostrate and breast tumors
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