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The process of adding a hydroxyl group to a non-polar molecule so that it becomes more soluble in water and is excreted from the organism. (Smooth ER)
Enzyme which cleaves signal peptide sequence from polypeptide chain as it enters the lumen.
Adjective used to describe mRNA which can code for several proteins, found in Prokaryotes.
Second step of protein synthesis where amino acids are added to a growing polypeptide chain.
Third step of protein synthesis where polypeptide and mRNA are released from the ribosome.
IF1, IF2, and IF3 bind to the 30S ribosomal subunit and GTP binds to IF2. (Enter numerical order of this step in prokaryotic translation)
mRNA and tRNA-Methionine bind to 30S ribosomal subunuit IF1 and IF3 are released.(Enter numerical order of this step in prokaryotic protein synthesis.)
Name of 3-9 purine nucleotides found upstream of start codon in mRNA. This sequence binds part of the 30S ribosomal subunit that has a pyrimidine rich rRNA segment.
GTP hydrolysis joins the 50S and 30S ribosomal subunits. IF2 is released and translation begins.(Enter numerical order of this step in prokaryotic protein synthesis.)
40S ribosomal subunit is complexed with eIF3 and eIF1A. eIF2-GTP binds with tRNA-met and binds to 40S subunit. This complex then binds to 5' end of mRNA.(Enter numerical order of this step in eukaryotic protein synthesis.)
eIF4 disassembles secondary structure found at the capped 5' end of the mRNA. This finalizes the 40S initiation complex. (Enter numerical order of this step in eukaryotic protein synthesis.)
The 40S initiation complex slides along the mRNA until the Kozak sequence and start codon are found. There the 60S ribosomal subunit joins and translation begins.(Enter numerical order of this step in eukaryotic protein synthesis.)
5'-ACCAUGG-3' Name of this sequence which 40S initiation complex searches for to bind 60S ribosomal subunit and begin translation.
Elongation factor needed to transport aminoacyl tRNA to A site of ribosome in prokaryotes. Carries two GTP molecules.
Elongation factor needed for translocation of tRNA from sites A and P to sites E and P in prokayrotes, bound to GTP.
Type of reaction which occurs when a release factor terminates eukaryotic protein synthesis.
Heat shock proteins
Class of molecular chaperones which assist in folding proteins into the correct conformation or refolding misfolded proteins.
The molecule which mutated or misfolded proteins are tagged with for degradation in the cytoplasm after they are deglycosylated.
Signal recognition particle
Protein which binds to signal peptide, ribosome, and receptor on ER. Protein blocks translation of mRNA until docked at rough ER.
Molecular chaperone of the rough ER which binds to hydrophobic regions of unfolded polypeptide to stabilize molecule.
Name of the addition or modification of sugar side-chains to newly folded proteins in the rough ER.
Start transfer sequence
Protein sequence which is bound by the signal recognition particle to be sent for another pass through the membrane.
The addition of a specific oligosaccharide to asparagine as part of post translational modification.
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