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Richter's: CLL to diffuse large cell lymphoma. or transforms to prolymphocytic leukemia
hypermetabolic syndrome, anemia, neutropenia, thrombocytopenia, hyperleukocytosis w/ mental status changes, hepatosplenomegaly, DIC, CNS, gums, leukemia cutis
good and bad cytogenetics of AML
good: t(15;17), t(8,21), inv(16). Bad: >5 abnormalities, deletion of 5 or 7, 11q23
hypermetabolic syndrome, anemia, neutropenia, thrombocytopenia, hyperleukocytosis w/ mental status changes, hepatosplenomegaly, tumor lysis syndrome
tumor lysis syndrome
in ALL. hyperuricemia (causes renal failure), hyperkalemia, hyperphosphatemia, hypocalcemia, high LDH
in ALL. causes TEL-AML1, recruitment of NCoR and HDACs- repression of AML-mediated transcription
good and bad ALL cytogenetics
good: t(12;21), hyperdiploidy. bad: t(9;22), 11q23, t(4;11) in infants, hypodiploidy, high WBCs
WHO classification of AML
1. w/ recurrent genetic abnormalities. 2: NOS. 3: AML with multilineage dysplasia (following MDS/MPD). 4: therapy-related
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