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USMLE World Review Antibodies

STUDY
PLAY
antimicrosomal
hashimotos thyroiditis
antithyroglobulin
hashimoto's thyroiditis
anti-DNA topoisomerase I antibody (anti-Scl-70)
Diffuse scleroderm - more aggressive
anti-centromere antibody
CREST - more benign
antinuclear antibodies
SLE - nontspecific
sjogren's, scleroderma, polymyositis, dermatomyosystis, arthritis, juvenile arthritis, mixed connective tissue disease
anti-dsDNA, anti-smith
specific for SLE
antihistone
drug-induced lupus
anti-igG
Rheumatoid factor
RA
anti-mitochondrial
primary biliary cirrhosis
anti-gliadin, anti-endomysial, antitransglutaminase
celiac
anti-basement membrane
goodpasture's
anti-desmoglein
pemphigus vulgaris
anti-jo-1
polymyositis, dermatomyositis
anti-SS-A (anti-ro)
sjogren's syndrome
ribonucleoprotein
anti-SS-B (anti-La)
sjogren's
ribonucleoprotein
anti-U1 RNP (ribonucleoprotein)
mixed connective tissue disease
anti-smooth muscle
autoimmune hepatitis
anti-glutamate decarboxylase
type 1 diabetes mellitus
c-ANCA - central anti-neutrophilic antibody
wegener's granulomatosis (proteinase-3)
p-ANCA - peripheral
churg-strauss syndrome
enzyme myeloperoxidase - microscopic polyangiitis
Ulcerative colitis
p-ANCA
thyroid-stimulating immunoglobulin
TSI stimulates thyroid production in Grave's
urine metanephrine
most specific for pheocromocytoma
24 hrs
also catecholamine
gamma glutamyl transpeptidase
cholestatic disease of the liver
alkaline phosphatase will be high also (same as bone dysfunction)
S-100 immunoreactivity
neural crest cell tumor
melanoma, schwannoma
CA-125
malignant ovarian epithelial cells in serous, endometriod, and clear cell carcinomas of the ovary
anti-cyclic citrullinated protein
rhematoid - more specific than RF
anti-bodies U1ribo-nucleo-protein
mixed connective tissue disease
anti-saccharomyces cerevisiae (ASCA)
Crohn's disease
CEA tumor marker
colorectal cancer
pancreatic adenocarcinoma (CA-19-9 as well)
5-HIAA in urine
Serotonin syndrome
prostatic acid phosphatase
prostate carcinoma
alpha-fetoprotein
hepatocellular carcinomas, nonseminomatous germ cells (testis)
beta-hCG
hydatidiform moles
choriocarcinomas
gestational trophoblastic tumors
alkaline phosphatase
metastases to bone, obstructive biliary disease
paget's disease of bone
bombesin
neuroblastoma, lung, gastric cancer
TRAP
tartrate-resistant acid phosphatase
hairy cell leukemia
CA-19-9
pancreatic adenocarcinoma