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21 terms

USMLE Pharm review 6

STUDY
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Death from a TCA is usually due to what?
V-fib and/or cardiogenic shock (inhibits cardiac fast NA channels)
cardiomyopathy associated with -rubicins?
dilated cardiomyopathy
Fexofenadine is what class of drug?
second generation antihistamine
Hydroyzine is what class of drug?
first generation antihistamine
promethazine is what class of drug?
first generation antihistamine
chlorpheniramine is what class of drug?
first generation antihistamine
first generation antihistamines?
hydroxyzine, promethazine, chlorpheniramine, diphenhydramine
warfarin is metabolized how?
P450
medication for atrial fibrillation that can cause heart block and diarrhea?
digoxin
medication for atrail fibrillation that can cause heart block and constipation?
Ca channel blocker (verapamil, -dipines, diltiazem)
dobutamine is of what drug class?
B-agonist prominently (some B2 and a1)
vitamin that will increase levodopa metabolism?
Vit B6
class of drug to treat dry mouth, flushed skin, dilated pupils that are non-reactive to light after being outdoors?
AChE inhibitor
long acting benzos?
CCDF (The bad grades for older people) chlordiazepoxide, clorazepate, diazepam, flurazepam
how do -afils affect vascular smooth muscle?
inhibit PDE blocking metabolism of cGMP (NO causes an increase in cGMP - reason why nitrates with PDE inhibitors cause problems)
K conductance is what phase of the ventricular action potential?
3
what antiarrhythmic modulates phase 0 of the ventricular action potential?
Class I (Na influx)
what antiarrhythmic modulates phase 1 of the ventricular action potential?
none (Na influx slows; K permeability increases)
what antiarrhythmic modulates phase 2 of the ventricular action potential?
Class IV (Ca influx and minimal K efflux- so Class 3 has minor influence)
What antiarrhythmic modulates phase 3 of the venricular action potential?
Class III (K efflux)
What antiarrhythmic modulates phase 4 of the ventricular action potential?
None - balanced ion flow