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drugs that increase cGMP

hydralazine, nitroprusside, nitroglycerin

aphrodisiac and erection enhancer

nitroglycerin, isosorbide dinitrate

K+ channel opener
-hyperpolarizes and relaxes vascular smooth muscle-


reduces insulin release
-can cause hyperglycemia-


D1 receptor agonist
-relaxes renal vascular smooth muscle-


can cause cyanide toxicity


release of nitric oxide

nitroprusside, nitrates

decreases preload

nitroglycerin, isosorbide dinitrate

blocks voltage-dependent L-type calcium channels
of cardiac and smooth muscle

calcium channel blockers

reduces muscle contractility

calcium channel blockers

what type of calcium channels do calcium channel blockers block?

L-type (voltage-dependent)

reduces afterload


effect of calcium channel blockers on vascular smooth muscle
by drug

nifedipine > diltiazem > verapamil

effect of calcium channel blockers on heart
by drug

verapamil > diltiazem > nifedipine

calcium channel blocker not used to tx arrhythmias


causes Monday Disease


freq given with beta blocker to prevent reflex tachycardia


causes reflex tachycardia

hydralazine, nitroglycerin, isosorbide dinitrate

causes lupus-like syndrome


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