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19 terms

Cards II Pharm

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drugs that increase cGMP
hydralazine, nitroprusside, nitroglycerin
aphrodisiac and erection enhancer
nitroglycerin, isosorbide dinitrate
K+ channel opener
-hyperpolarizes and relaxes vascular smooth muscle-
diazoxide
reduces insulin release
-can cause hyperglycemia-
diazoxide
D1 receptor agonist
-relaxes renal vascular smooth muscle-
fenoldopam
can cause cyanide toxicity
nitroprusside
release of nitric oxide
nitroprusside, nitrates
decreases preload
nitroglycerin, isosorbide dinitrate
blocks voltage-dependent L-type calcium channels
of cardiac and smooth muscle
calcium channel blockers
reduces muscle contractility
calcium channel blockers
what type of calcium channels do calcium channel blockers block?
L-type (voltage-dependent)
reduces afterload
hydralazine
effect of calcium channel blockers on vascular smooth muscle
by drug
nifedipine > diltiazem > verapamil
effect of calcium channel blockers on heart
by drug
verapamil > diltiazem > nifedipine
calcium channel blocker not used to tx arrhythmias
nifedipine
causes Monday Disease
nitrates
freq given with beta blocker to prevent reflex tachycardia
hydralazine
causes reflex tachycardia
hydralazine, nitroglycerin, isosorbide dinitrate
causes lupus-like syndrome
hydralazine