5 Written questions
5 Matching questions
- Interstitial fluid volume = in between cells?
- Body weight normal is ____ Body weight current before patient was volume depleted
- when treating Hypovolemic Hypotonic Hyponatremia with Diuretics, what has to be considered?
- Hypertonic, can be defined as?
- ratio of water to Na+, are related to what abnormality?
- a 3/4 ECFV
- b 15%
- c -Loop diuretics: proportional loss of Na+ and water (don't become hyponatremic!)
-Thiazides: more Na+ loss than water (high chance of having a low serum Na)
- d -ECF sodium concentration (hypernatremia vs. hyponatremia) are due to problems with water control mechanisms
- e -solutes outside-more water inside cells and cells shrink-brain can shrink and cause damage
5 Multiple choice questions
- -Indicated for hypervolemic or euvolemic hyponatremia
-Conivaptan (Vaprisol®): Non-selective V1A and V2 receptor antagonist; IV only
-Tolvaptan (Samsca®): Selective V2 receptor antagonist; oral only also approved in patients with SIADH (but not first line option)
- -Correct hypercalcemia and hypokalemia
-Create mild ECFVd with thiazide diuretic and dietary Na+ restriction ↓ urine volume
-Indomethacin 50 mg po tid (increase sensitivity to ADH)
-Amiloride 5 - 10 mg po daily (lithium induced DI, antagonizes Li effects on kidney tubules)
- 2/3 TBW
- -Ability of combined effect of all solutes to generate osmotic driving force that causes H2O movement from one compartment to another (if osmolality is high in EC-compartment, compared to what's inside cells, will be hypertonic)
- -Cases of abnormal ECFV size (hypervolemia vs. hypovolemia) are due to problems with the sodium control mechanism
5 True/False questions
what is the treatment goal when Hypovolemic Hypotonic Hyponatremia is being treated? → -Administer 0.9% NaCl at 200 - 400 ml/h until symptoms of hypovolemia improve, then lower to 100 - 150 ml/h (calculate volume deficit)
-No greater than 12 mEq/L/day increase in serum Na+
-Monitor serum Na+ q2-4h, signs of hypovolemia, volume overload
Plasma/intravascular volume (vessels where blood is) → 1/4 ECFV
Extracellular fluid volume (ECFV= outside cells) ? → 1/3 TBW
Serum osmolality (calculated) (serum=blood in vessels) is calculated using what equation? → 1/4 ECFV
Central diabetes insipidus (causes high Na+) can be defined as? → -Absence or deficiency of ADH leading to excessive renal water loss and hypernatremia, urinate a lot = causing high [Na] hypernatremia
-TCA-antidepressants = cause SIADH commonly