decrease CRH and ADH; increase appetite
maintain sensitivity to vasoconstrictors
fetal lung development
increase resorption;decrease formation
catabolic, decrease insulin sensitivity
decrease collagen synthesis
most common mutation in the steroidogenic pathway
21β-hydroxylase, leaving you with an excess of 17-hydroxyprogesterone, leading to lots of androstenedione
what is CBG
protein with that binds to cortisol with a high affinity
what is prohormone convertase 1 (PC1)?
the enzyme that directs sniping of POM-C to ACTH
At what time does cortisol peak?
congenital adrenal hyperplasia
defect in 21β-hydroxylase, leaving you with an excess of 17-hydroxyprogesterone, leading to lots of androstenedione
clinical features of primary adrenocortical insufficiency
1. weakness, fatigue, anorexia, weight loss
4. GI disturbances
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