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16 terms

Phys_Effects of glucocorticoids plus other adrenal cortex facts

STUDY
PLAY
CNS
decrease CRH and ADH; increase appetite
CV
maintain sensitivity to vasoconstrictors
Liver
increase gluconeogenesis
lungs
fetal lung development
pituitary
decrease ACTH
kidney
increase GFR
bone
increase resorption;decrease formation
muscle
catabolic, decrease insulin sensitivity
immune system
suppression
connective tissue
decrease collagen synthesis
most common mutation in the steroidogenic pathway
21β-hydroxylase, leaving you with an excess of 17-hydroxyprogesterone, leading to lots of androstenedione
what is CBG
protein with that binds to cortisol with a high affinity
what is prohormone convertase 1 (PC1)?
the enzyme that directs sniping of POM-C to ACTH
At what time does cortisol peak?
7:00 a.m.
congenital adrenal hyperplasia
defect in 21β-hydroxylase, leaving you with an excess of 17-hydroxyprogesterone, leading to lots of androstenedione
clinical features of primary adrenocortical insufficiency
1. weakness, fatigue, anorexia, weight loss
2. hyperpigmentation
3. hypotension
4. GI disturbances