To increase serum Ca. secretion increased in low Ca, and decreased in high Ca states.
What are the symptoms for hypercalcemia?
MISHAP •Malignancy •intoxication with vit D •Sarcoidosis •Hyperthyroidism •Alkali (milk-alkali syndrome) •Paget's dz
What is the MCC of hypercalcemia?
How do malignancies cause hypercalcemia?
•metastatic tumor cells → cytokine release → osteolytic metastasis→ osteolysis •release of PTH-related protein (PTHrP) by solid tumors (Sq cell cancers) --- appears in the absence of osteolytic metastasis called humoral hypercalcemia of malignancy
***What is Familial Hypocalciuric Hypercalcemia?
A mutation in the calcium sensing receptor gene (CaSR) causing the parathyroid gland to have decreased sensitivity to extracellular calcium levels
What histological marker do you expect to find in Osteitis Fibrosa Cystica?
What are the symptoms of Osteitis Fibrosa Cystica?