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21 terms

Lecture 7: Long Term Potentiation

Neurophysiology and Behavior
STUDY
PLAY
synaptogensis
the neural basis of learning and memoryhave been linked with the processes of long-term potentiations and________________.
Long Term Potentiation
refers to sustained changes in the efficiency of synaptic communication that results from activation of a synapse
Experience
__________ activates particular synapses throughout the brain.
activation increases
this synaptic ___________ ___________ the ease with which involved synapses communicate
synaptic efficiencies
changed __________ ____________ explain the learned responses and memories the result from experience.
stimulating pre synaptic
Research on Long Term Potentiation often involved ________ a ___ _________ neuron while recording from a post synaptic neuron.
recording post synaptic
Research on Long Term Potentiation often involved stimulating a presynaptic neuron while _________ from a ____ ____________ neuron
base line firing rates
Pre-synaptic test stimulations are conducted to measure _______ ________ post synaptic ______ _________.
more intensely
After measuring the baseline post-synaptic firing rate, the pre-synaptic neuron is ______ ________ stimulated for a period of time to simulate a "learning experience"
greater post synaptic
After the pre-synaptic neuron is more intensely stimulated for a period of time to simulate a learning experience, test stimulations are conducted at the base line level to reveal __________ _______ __________ activation than before the intense simulation (LTP)
hippocampal glutimate
To consider the neural basis of LTP, we'll focus on ________ neurons that communicate with __________.
Glutimate
_________ binds with two types of post-synaptic receptors: AMPA and NMDA
AMPA
________ receptors normally bind with glutimate and open NA+ channels the DEPOLARIZE the cell.
NMDA
________ receptors are normally blocked with Mg+ ions that prevent binding with glutimate.
removal NMDA
Strong activation of the post-synaptic neuron results in _________ of the Mg+ ions and frees the _________ receptors to bind with the glutimate.
Calcium second messengers
Binding of the NMDA receptors with glutimate causes ______ channels to open, which in turn activates __________ __________. (metabotropic)
Metabotropic second messengers
________ _________ _________ that result from NMDA receptor activation causes synaptic changes that are the basis of LTP
AMPA
the second messengers that result from NMDA receptor activation cause synaptic changes that are the basis for LTP by: increased sentivity to _______ receptors
AMPA
the second messengers that result from NMDA receptor activation cause synaptic changes that are the basis for LTP by: formation of new _______ receptors
retrograde messengers
the second messengers that result from NMDA receptor activation cause synaptic changes that are the basis for LTP by: __________ ________ being sent to the presynaptic neuron that can cause increased glutimate release
increased glutimate
the second messengers that result from NMDA receptor activation cause synaptic changes that are the basis for LTP by: retrograde messengers being sent to the presynaptic neuron that can cause __________ __________ release