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Saunders: CH77 Psychiatric Medications

Terms in this set (34)

- what class of Rx's may be used in pt's w/ Alzheimer's disease to improve cognitive functions in the early stages?

DONEPEZIL (Aricept)*:
- an inhibitor of acetylcholinesterase used to txt mild-
moderate dementia of Alzheimer's disease.
- Side/Adverse = N&D.
- can slow HR through its Vagotonic effect.

GALANTAMINE (Razadyne)*:
- an inhibitor of Cholinesterase used to txt mild-mod
Dementia of alzheimer's disease.
- Side/Adverse = N&V, diarrhea, anorexia, weight loss.
- can cause Bronchoconstriction; used w/ caution in pt
w/ Asthma & COPD.

MEMANTINE (Namenda)*:
- N-Methyl-D-aspartate (NMDA) receptor antagonist for
txt of moderate to severe Dementia of Alzheimer's
disease.
- Side/Adverse = dizziness, headache, confusion, & GI
disturbances.
- should NOT be used in combination w/ other NMDA
antagonists (Amantadine or Ketamine [Ketalar]); such
combinations produce undesirable additive effects.
- Sodium Bicarbonate & other meds that [alkalinize]
the urine can decrease renal excretion of memantine
--> accumulation to Toxic levels.

RIVASTIGMINE (Exelon)*:
- Cholinesterase inhibitor used to txt mild-moderate
Dementia of alzheimer's disease.
- Side/Adverse = N&V, diarrhea, abdominal pain, &
anorexia.
- used w/ Caution if pt has (PUD, bradycardia, sick sinus
syndrome, Urinary obstruction, & Lung disease) b/c it
enhances Cholinergic transmission, intensifying sxs of
these disorders.

TACRINE (Cognex)*:
- a centrally acting Cholinesterase inhibitor to txt mild-
moderate Dementia o Alzheimer's disease.
- Side/Adverse = Ataxia, loss of appetite, N&V, diarrhea.
- An Adverse effect = Hepatotoxicity; liver function
studies need to be monitored.