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Transmission of Corynebacterium diphtheriae:
2) contact w/ shed skin crusts
a) pseudomembrane-leathery coating
occluding respitatory tract
b) toxin dissemination into blood stream
Gram + bacilli
non spore forming
tend to be pleomorphic
Exotoxin of C. diphtheriae
Consists of 2 polypeptide fragments
Fragment B binds to target cells in the heart and nervous system
Fragment A interacts with the cytoplasm and arrests protein synthesis.
C. diphtheria complication 1
a film the develops in the pharynx from solidification of fluid
this can cause asphyxiation
C. diphtheria complication most dangerous
toxin absorbed from the throat and carred via blood to organ..primarily heart and nerves.
Corynebacterium diphtheriae Morphology
1. gram (+) rods (very pleomorphic and club-shaped)
2. non-spore forming
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