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12 terms

Corynebacterium diphtheriae

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Pathogenicity of Corynebacterium diphtheriae:
1) Diphtheria
2) Cutaneous Diptheria
Portals of Corynebacterium diphtheriae:
1) nose/mouth
2) compromised skin
Transmission of Corynebacterium diphtheriae:
respiratory disease
1) droplets
2) contact w/ shed skin crusts
3) fomites
Diphtheria:
a) pseudomembrane-leathery coating
occluding respitatory tract
b) toxin dissemination into blood stream
Cutaneous Diptheria:
desert sore
a) usually self limiting
b) can lead to septicemia
Corynebacterium diphtheriae
Gram + bacilli
non spore forming
tend to be pleomorphic
Catalase +
mycolic acids
Exotoxin of C. diphtheriae
Consists of 2 polypeptide fragments
Fragment B binds to target cells in the heart and nervous system
Fragment A interacts with the cytoplasm and arrests protein synthesis.
C. diphtheria complication 1
Pseudomembrane
a film the develops in the pharynx from solidification of fluid
this can cause asphyxiation
C. diphtheria complication most dangerous
toxemia
toxin absorbed from the throat and carred via blood to organ..primarily heart and nerves.
Corynebacterium diphtheriae Morphology
1. gram (+) rods (very pleomorphic and club-shaped)
2. non-spore forming
3. non-motile
Corynebacterium diphtheriae Transmission
respiratory droplets from a carrier
Corynebacterium diphtheriae Metabolism
1. facultative anaerobe
2. catalase (+)