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Polyostotic fibrous dysplasia, precocious puberty, cafe-au-lait spots, short stature, young girls
Guillain-Barre (inc protein in CSF with only modest inc in cell count)
Multiple myeloma (kappa or lambda Ig light chains in urine), Waldenstrom's macroglobulinemia (IgM)
Bence Jones proteins
Hemorrhage causes brown color of osteolytic cysts: 1. Hyperparathyroidism 2. Osteitis fibrosa cystica (von Recklinghausen's disease)
"Brown tumor" of bone
Multiple sclerosis (nystagmus, intention tremor, scanning speech), cholangitis (jaundice, RUQ pain, fever)
Parkinson's disease (basal ganglia disorder..rigidity, resting tremor, bradykinesia)
Depigmentation of neurons in substantia nigra
beta-thalassemia, sickle cell anemia (extramedullary hematopoiesis)
"Hair-on-end" (crew-cut) appearance on x-ray
Anencephaly, spina bifida (neural tube defects)
Increased alpha-fetoprotein in amniotic fluid/maternal serum
Gout, Lesch-Nyhan syndrome, myeloproliferative disorders, loop and thiazide diuretics
Increased uric acid levels
Syphilis..overaggressive treatment of an asymptomatic patient that causes symptoms due to rapid lysis
Multiple myeloma (called the M protein; usually IgG or IgA), MGUS (monoclonal gammopathy of undetermined significance), Waldenström's (M protein = IgM) macroglobulinemia
Monoclonal antibody spike
Wegener's and Goodpasture's (hemoptysis and glomerular disease)
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis
Scurvy (ascorbic acid, vitamin C deficiency)--vitamin C is necessary for hydroxylation of proline and lysine in collagen synthesis
Swollen gums, bruising, poor wound healing, anemia
Visceral cancer, pancreatic adenocarcinoma (migratory thrombophlebitis), hypocalcemia (carpal spasm)
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