Strong affinity for calcium: discoloration of permanent teeth and tooth enamel in fetuses and children, or nursing infants if taken by the mother, may retard fetal skeletal development if taken during pregnancy.
Alteration in intestinal flora may result in: Superinfection (overgrowth of nonsusceptible organisms such as Candida), Diarrhea, and Pseudomembranous colitis. (Add probiotic)
May also cause: Vaginal candidiasis, Gastric upset, Enterocolitis, Maculopapular rash, and other effects. Most significant, especially with Doxycycline, is photosensitivity.
Finish medication. Take missed dose ASAP. Don't double dose. Don't share medication. Avoid taking milk or other dairy products. Avoid taking antacids, zinc, calcium, magnesium- or aluminum-containing meds, sodium bicarbonate, and iron supplements within 1-3 hr or oral tetracycline. Notify doc if rash, diarrhea, abdominal cramping, fever, or bloody stool occur. Use additional contraceptive. Minocycline commonly causes dizziness or unsteadiness. Avoid driving or activities that require alertness. Use sunscreen or protective clothing. Report signs of superinfection. Notify doc if taking any supplements or OTC meds. Notify doc of med regimen before treatment or surgery. Notify doc if symptoms don't improve. Discard outdated or decomposed meds. Malaria Prophylaxis: avoid being bitten by mosquitoes by using protective equipment. Doxycycline taken before, during, and after visiting malarious area; not exceeding 4 months. GI effects, primarily with erythromycin: Nausea, vomiting, diarrhea, hepatotoxicity, flatulence, jaundice, anorexia.
Azith. and Clari.: fewer GI adverse effects, longer duration of action, better efficacy, better tissue penetration.
Hepatotoxicity is rare. Anorexia comes because of abdominal discomfort.
Careful when combining with Warfarin, antihistamines, and antifungals.
Finish the medication and take it as prescribed.
Assess for signs and symptoms of Superinfection: fever, perineal itching, cough, lethargy, or any unusual discharge.
Take with at least 6-8 oz of water to help with absorption.
Monitor for adverse effects including: diarrhea, nausea, vomiting or drug interactions.
Monitor for therapeutic effects: improvement of signs and symptoms of infection, return to normal vital signs, negative culture and sensitivity tests, and disappearance of fever, lethargy, drainage, and redness.