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Micro Lec 25: Oncogenic DNA Viruses

Terms in this set (25)

P53; Rb
Key genes for maintaining integrity of genome
Flaviviridae (HCV)
RNA oncogenic virus(es): (Adenoviridae|Flaviviridae|Hepadnaviridae|Herpesviridae)
Retroviridae
RNA oncogenic virus(es): (Papovaviridae|Poxiviridae|Retroviridae)
Adenoviridae; Hepadnaviridae (HCC); Herpesviridae
DNA oncogenic virus(es): (Adenoviridae|Flaviviridae|Hepadnaviridae|Herpesviridae)
Papovaviridae (papillomaviruses, polymaviruses); Poxiviridae (myxomas, fibromas)
DNA oncogenic virus(es): (Papovaviridae|Poxiviridae|Retroviridae)
HPV (Human Papillomavirus)
Small non-enveloped virus; ds circular DNA; ubiquitous; can be oncogenic; mostly latent, transient infections; minority develop to cancer
ds (circular) DNA; non-enveloped
HPV is (_/+/-) (ds/ss) (DNA/RNA); (enveloped/non-enveloped)
Contact inhibition; motility; proliferation
Characteristics of cancer cells; can be determined in culture
E5; E6; E7
HPV proteins involved in oncogenic activity; important for virus and integration; together are strongly oncogenic (3)
E6
(E5/E6/E7) is not an oncogene by itself; required for efficient immortalization; main target is p53
E7
(E5/E6/E7) is a weak oncogene (compared to RSV); aggregates Rb (sequesters it); deregulated cell growth; starts cascade leading to transformation
E5
(E5/E6/E7) induces some transformed phenotypes in established cells; can increase proliferative capacity of human keratinocytes; PDGF receptor main target
E5
(E5/E6/E7) is normally a protein on EGF receptor; inhibits recycling of receptors (remains phosphorylated at cell surface)
VLP (virus-like particles; vaccine non-infectiouns)
HPV vaccine is (inactivated virus/live attenuated virus/VLP)
EBV
Burkitt's lymphoma (AfBL) is caused by this virus
EBV
Nasopharyngeal carcinoma (NPC) is caused by this virus
EBV; immunocompromised
B-cell lymphomas are caused by this virus, in ____ patients
EBV
Hodgkin's disease is caused by this virus
Ig genes (much more than normal)
Most BL tumors contain translocations, activating c-myc gene, then shares promoter with these genes
Malaria (enlarged pool of cells proliferating without control)
EBV is more likely to develop into BL when one is co-infected with ____
LMP-1
(EBNA-1/EBNA-2/EBNA3/LMP-1) is the EBV oncogene; molecular mimicry of CD40 but doesn't need ligand; reduced level of control; will lead to immortalization
CD40
The EBV oncogenic protein LMP-1 mimics this cell surface protein in B cells; constitutively active; produces same intracellular signaling
Inactivation of tumor suppression genes
HPV is oncogenic typically by (activation of growth receptor/inactivation of tumor suppression genes/translocation of c-myc)
Translocation of c-myc
BL is oncogenic typically by (activation of growth receptor/inactivation of tumor suppression genes/translocation of c-myc)
Birth canal passage
An 11 year old boy with a neck growth containing HPV DNA was infected through (birth canal passage/placenta/breast feeding)
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