What is the rationale for the use of cholinesterase inhibitors in dementia?
- the acetylcholine (ACh) M1 sub receptor is key for cortico-cerebral memory functions
- there is decreased cholinergic function in the degenerative dementias, especially Alzheimer's
- acetylcholinesterase and butyrylcholinesterase are the enzymes that break down acetylcholine
- inhibiting the cholinesterase increases acetylcholine