Bone pain (back or chest, less extremity) 60%, pain in movement, not at night, height reduced by vertebral collapse. 80% of patients show abnormal radiograph. Focal osteolytic lesions (high osteoblasts, low osteoclasts) 60%, osteoporosis, pathologic fractures, compression fractures of the spine 20%, weakness and fatigue (32%), anemia, fever (<1%), bleeding uncommon, weight loss 24%, complications: hypercalcemia, renal insufficiency, amyloidosis.