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regulation of cell cycle by...?
CDKs, cyclins: phase-specific cyclins activate CDKs, bind up RB protein which is then released from elongation factors so they can transcribe
specific modifications made in Golgi?
- mod N-oligosacc on asparagine
- adds O-oligosacc to serine and threonine
- adds mannose-6-phosphate to lysosomal proteins
sx: coarse facial features, clouded corneas, restricted joint mvmt, high plasma lysosomal enzymes?
cause of Chediak Higashi?
microtubule polymerization defect so decreased phagocytosis, may be sparked by EBV infx
name some drugs that act on microtubules
- Mebendazole (worms)
- Griseofulvin (fungi)
- Vincristine (cancer)
- Paclitaxel (breast ca)
- Colchicine (gout)
direct inhibitors of Na-K ATPase on plasma membrane?
- cardiac glycosides (digox) = indirect inhib of Na/Ca exchange so increased Ca and cardiac contractility
sequence for collagen alpha chains?
Gly-X-Y where X and Y are proline, hydroxyproline, or hydroxylysin
proper collagen structure requires what vitamin and why?
vitamin C, to hydroxylate proline and lysine residues
hyperextensible skin, tendency to bleed, hypermobile joints, berry aneurysms?
Ehlers Danlos (type III collagen defect)
multiple fractures w/min trauma, blue sclerae, hearing loss, dental defects?
osteogenesis imperfecta (type I collagen defect)
sx of osteogenesis imperfecta?
1) *multiple fractures w/min trauma
2) *blue sclerae
3) hearing loss
4) dental defects
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