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44 terms

Biochem Cellular

STUDY
PLAY
regulation of cell cycle by...?
CDKs, cyclins: phase-specific cyclins activate CDKs, bind up RB protein which is then released from elongation factors so they can transcribe
classic tumor suppressors?
Rb, p53, inhibit G1 to S progression (checkpoint)
function of RER?
synth of secretory proteins
site of synth of secretory proteins?
RER
function of SER?
steroid synth and detox
site of steroid synth and detox?
SER
specific modifications made in Golgi?
- mod N-oligosacc on asparagine
- adds O-oligosacc to serine and threonine
- adds mannose-6-phosphate to lysosomal proteins
what targets molecule to lysosome?
mannose-6-phosphate addition in Golgi
cause of I-cell disease?
lysosomal storage disease, no mannose-6-phosphate added
if no mannose-6-phosphate added to lysosome proteins?
I-cell disease
sx: coarse facial features, clouded corneas, restricted joint mvmt, high plasma lysosomal enzymes?
I-cell disease
cause of Chediak Higashi?
microtubule polymerization defect so decreased phagocytosis, may be sparked by EBV infx
name some drugs that act on microtubules
- Mebendazole (worms)
- Griseofulvin (fungi)
- Vincristine (cancer)
- Paclitaxel (breast ca)
- Colchicine (gout)
recurrent pyogenic infx, partial albinism, peripheral neuropathy?
Chediak Higashi
cause of Kartagener's?
immotile cilia d/t dynein arm defect
infertility, bronchiectasis, recurrent sinusitis, association with situs inversus?
Kartagener's
vimentin stain?
CT
desmin stain?
muscle
cytokeratin stain?
epithelial cells
GFAP stain?
neuroglia
neurofilament stain?
neurons
stain for CT?
vimentin
stain for muscle?
desmin
stain for epithelial cells?
cytokeratin
stain for neuroglia?
GFAP
stain for neurons?
neurofilament
direct inhibitors of Na-K ATPase on plasma membrane?
- cardiac glycosides (digox) = indirect inhib of Na/Ca exchange so increased Ca and cardiac contractility
type I collagen?
bone, skin, tendon
type II collagen?
cartilage
type III collagen?
reticulin
type IV collagen?
basement membrane
collagen in bone, skin, tendon?
type I
collagen in cartilage?
type II
collagen in reticulin?
type III
collagen in basement membranes?
type IV
defect in type IV collagen?
Alport's (nephritis, ocular defects, deafness)
sequence for collagen alpha chains?
Gly-X-Y where X and Y are proline, hydroxyproline, or hydroxylysin
proper collagen structure requires what vitamin and why?
vitamin C, to hydroxylate proline and lysine residues
hyperextensible skin, tendency to bleed, hypermobile joints, berry aneurysms?
Ehlers Danlos (type III collagen defect)
brittle bone disease?
osteogenesis imperfecta (type I collagen defect)
multiple fractures w/min trauma, blue sclerae, hearing loss, dental defects?
osteogenesis imperfecta (type I collagen defect)
sx of osteogenesis imperfecta?
1) *multiple fractures w/min trauma
2) *blue sclerae
3) hearing loss
4) dental defects
fibrillin defect?
Marfan's
what amino acids are prevelant in elastin?
proline, glycine