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Impact of the drugs on the body, determines nature and intensity of the response


Highly desirable characteristics; high selectivity= fewer side effects, Drugs act through receptors like a lock and key.


Study of drug movement throughout the body. MADE


makes a particular treatment or procedure undesirable

How does kidney disease effect pharmacokinetics?

Kidneys are the most important organ in the body for drug excretion

What is the Drug schedule from the Controlled Substances act of 1970

Set of rules for the manufacturing and distribution of drugs considered to have potential for abuse. Schedule I- not accepted in the US and high potential for abuse, II-V have acceptable medical applications but still potential for abuse. Greater the # less chance for abuse.

"off-label" use


Drug information resources to use

Pharmacist, Poison Control, PDR, Drug Facts

First-pass effect

Rapid hepatic inactivation of certain oral drugs


Time required for the amount of drug in the body to decrease by 50%, Short-half life= leaves body quickly, Long-half life= leaves body slowly

Therapeutic index-what does this mean?



Molecules that activate receptors and mimic actions of the body's own regulatory system


Prevent activation of receptors and block the actions of endogenous regulatory molecules or blocking actions of drugs

Receptor binding does what?


Grapefruit juice effect

Inhibits the metabolism of certain drugs raising blood levels

Anaphylaxis-when can it occur, how is it treated?

Severe allergy= hypotension, bronchoconstriction and edema of glottis=epinephrine injected IM

What does hepatotoxic mean?


What are signs and symptoms of liver failure?

Jaundice, dark urine, light-colored stools, nausea, vomiting, malaise, abdominal discomfort, loss of appetite

What is an allergic reaction, how much of a drug does it take to cause an allergic rxn?

Immune response

When do you suspect an adverse drug reaction?

Unintended and undesirable effect that occurs at normal drug doses

What do you review before medication administration?


Placebo effect




Drug tolerance


Accurate drug dosing is based on the patient's _________?


Review cholinergic and adrenergic receptor location and functions


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