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Highly desirable characteristics; high selectivity= fewer side effects, Drugs act through receptors like a lock and key.
How does kidney disease effect pharmacokinetics?
Kidneys are the most important organ in the body for drug excretion
What is the Drug schedule from the Controlled Substances act of 1970
Set of rules for the manufacturing and distribution of drugs considered to have potential for abuse. Schedule I- not accepted in the US and high potential for abuse, II-V have acceptable medical applications but still potential for abuse. Greater the # less chance for abuse.
Time required for the amount of drug in the body to decrease by 50%, Short-half life= leaves body quickly, Long-half life= leaves body slowly
Prevent activation of receptors and block the actions of endogenous regulatory molecules or blocking actions of drugs
Anaphylaxis-when can it occur, how is it treated?
Severe allergy= hypotension, bronchoconstriction and edema of glottis=epinephrine injected IM
What are signs and symptoms of liver failure?
Jaundice, dark urine, light-colored stools, nausea, vomiting, malaise, abdominal discomfort, loss of appetite
What is an allergic reaction, how much of a drug does it take to cause an allergic rxn?
When do you suspect an adverse drug reaction?
Unintended and undesirable effect that occurs at normal drug doses
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