Create an account
Sudden and unexpected natural death - why is toxicological analysis is necessary in all such cases?
Died "of" a particular disease vs. died "with" a particular disease
May occur in an individual with significant natural disease, but the death was not expected at that time
Most common systems involved in sudden unexpected natural death
Cardiovascular system, Respiratory system, Central nervous system
Atherosclerotic coronary artery disease (ASCAD)
Disease in blood vessels that supply the heart. Majority of sudden natural deaths investigated by medical examiner offices
Atherosclerotic coronary artery disease - medical history
Often no history of previously diagnosed coronary disease
Most common finding (ASCAD)
at least one coronary artery with at least 75% stenosis. May or may not have evidence of myocardial tissue damage.
The finding of severe atherosclerotic coronary artery disease
does not rule out death due to other causes
ASCAD Cause of death
Cardiac arrhythmia due to severe atherosclerotic coronary artery disease (or atherosclerotic cardiovascular disease)
Enlarged heart with septum thickened more than left ventricular free wall
Hypertrophic cardiomyopathy victims are often
young athletes dying suddenly during or immediately after physical exertion
Clots arise from deep venous thrombosis in the lower extremities, dislodge, and travel to the pulmonary artery and into the lungs
If 60% of the pulmonary vasculature is suddenly blocked
the heart cannot pump blood through the lungs, leading to cardiovascular collapse
Asthma death is caused by
obstruction of the airways by muscular constriction and mucus production such that air can get into but not out of the lung
Please allow access to your computer’s microphone to use Voice Recording.
Having trouble? Click here for help.
We can’t access your microphone!
Click the icon above to update your browser permissions and try again
Reload the page to try again!Reload
Press Cmd-0 to reset your zoom
Press Ctrl-0 to reset your zoom
It looks like your browser might be zoomed in or out. Your browser needs to be zoomed to a normal size to record audio.
Please upgrade Flash or install Chrome
to use Voice Recording.
For more help, see our troubleshooting page.
Your microphone is muted
For help fixing this issue, see this FAQ.
Star this term
You can study starred terms together