Describe the framework for Burkitt's lymphoma?
P: Adolescents or young adults, starry sky appearance, sheets of lymhocytes with interspersed macrophages, Jaw lesion in africa, abdomen/pelvic mass in sporadic form.
M: t(14:18) of the c-myc gene moves to the heavy Ig chain, associated with EBV
C: Leukemic phase rare, prognosis is rare, abdominal lesions can cause bowel obstruction, jaw lesions: loosening of teeth
Dx: PCR/Fish for c-myc, bone marrow biopsy, B markers (IgM)
Tx:CDOX regimen, rituxumab (monclonal against CD20)