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What is the difference between a Southern blot, Northern blot, and Western blot?


Southern = DNA sample, DNA probe
Northern = RNA sample, DNA probe
Western = Protein sample, Antibody probe

What type of test uses a known antigen to discern the presence of an antibody?


What type of test is performed in order to diagnose chromosomal imbalances?


What are the mitochondrial inheritance defects?

1. Mitochondrial myopathies (ragged-red muscle fibers seen on biopsy)
2. Leber hereditary optic neuropathy
3. Leigh syndrome (subacute sclerosing encephalopathy)

Two pts have the same mutation on chromosome 15 but have different phenotypic expressions. One patient received the mutation from the father while the other received the mutation from the mother. What is this an example of?


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