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Genetics Exam #4 -- part 2

Terms in this set (63)

7 patterns of hepatic injury
Degeneration and intracellular accumulation, necrosis and apoptosis, regeneration, inflammation, fibrosis, cirrhosis, ductular retraction
Common manifestation of liver disease, yellow discoloration of skin and whites of eyes, serum bilirubin over 2.0mg/dL
Jaundice
Causes of Jaundice
hemolytic anemia, neonatal jaundice, hepatitis, inflammatory destruction of bile ducts
Systemic retention of not only bilirubin, but also other solutes eliminated in bile, particularly bile salts and cholesterol
Cholestasis
MCC chronic liver disease
hepatic dysfunction without overt necrosis
80-90% of functional capacity loss
Massive hepatic necrosis
Hepatic failure
Multiple organ failure, coagulopathy, hepatic encephalopathy, hepatorenal syndrome
complications of hepatic failure
Scarring and fibrosis of the liver, with altered liver architecture and function, caused by chronic liver disease
Cirrhosis
3 defining characteristics of cirrhosis
Bridging fibrous septa, parenchymal nodules, disruption of architecture of entire liver
High blood pressure in portal vein
Prehepatic, intrahepatic and post hepatic causes
Portal HTN
MCC of Intra Hepatic Portal HTN
Cirrhosis
ascites, portosystemic venous shunts, splenomegaly, hepatic encephalopathy, caput medusae, hemorrhoids, esophageal varices
clinical features of Portal HTN
the foremost primary liver infection
MCC of liver cancer (Hep B and C)
MCC for liver transplantation (Hepatitis C)
Viral hepatitis
a small percent of people infected with HAV or HBV infection may develop massive liver necrosis and acute liver failure
Fulminant viral hepatitis
fatigue; less commonly malaise, loss of appetite, bouts of mild jaundice
remission; slow progression; or cirrhosis and death
Chronic viral hepatitis
Mild to severe chronic hepatitis
Female predominance
Absent serological markers of viral infection
Elevated IgG
Autoimmune hepatitis
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