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down syndrome

acute myelogenous leukemia, acute lymphoblastic leukemia

xeroderma pigmentosum and albinism

melanoma, basal cell carcinoma, squamous cell carcinoma***

chronic atrophic gastritis, prenicious anemia, postsurgical gastric remnants

gastric adenocarcinoma

tuberous sclerosis (facial angiofibroma, seizures, mental retardation)

astrocytoma, angiomyolipoma, cardiac rhabdomyoma

actinic keratosis

squamous cell carcinoma of skin

barret's esophagus

esophageal adenocarcinoma

cirrhosis (alcoholic, hepatitis B or C)

hepatocellular carcinoma

ulcerative colitis

colonic adenocarcinoma

plummer vinson syndrome (atrophic glossitis, esophageal webs, anemia, due to iron deficiency)

squamous cell carcinoma of esophagus

paget's disease of bone

secondary osteosarcoma, fibrosarcoma

immunodeficiency states

malignant lymphomas


aggressive malignant lymophmas (non Hodgkin's)

Autoimmune disease (Hashimoto's thyroiditis, myasthenia gravis)


acanthosis nigricans

visceral malignancy (stomach, lung breast uterus)

dysplastic nevus

malignant melanoma

radiation exposure

sarcoma, papillary thyroid cancer

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