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What are etiologic factors for male urethral cancer?
Chronic inflammation, urethral stricture, urethritis, STD (HPV-16)
What are presenting symptoms of male urethral cancer?
Urethral bleeding, palpable mass, obstructive voiding
Tumors in the bulbomembraneous urethra make up what % of male urethral cancer and are of what histologic subtype?
SCC - 80%
TCC - 10%
Adeno - 10%
Tumors in the penile urethra make up what % of male urethral cancer and are of what histologic subtype?
SCC - 90%
TCC - 90%
Tumors in the prostatic urethra make up what % of male urethral cancer and are of what histologic subtype?
TCC - 90%
SCC - 10%
What nodes do anterior and posterior urethra drain to?
Ant - Sup and deep inguinal
Post - Pelvic nodes
Describe the N staging for male urethral cancer
N1 - single node <2cm
N2 - single node 2-5 or multiple <5
N3 - node >5
T/F prophylactic or early ILND has been shown to have benefit with anterior urethral cancer?
F - only indicated with palpable nodes
What are etiologies of female urethral cancer?
Leukoplakia, chronic irritation, caruncles, polyps, HPV
What is the division of the female urethra?
Ant - distal 2/3 (can be excised without compromising continence)
Post - proximal 1/3
Female post urethral cancer primarily drains to what lymph nodes?
Ext iliac, then hypogastric and obturator
What is the histology of female urethral cancer?
SCC - 50-70%
Adeno - 25% (increased in urethral diverticulum)
TCC - 10%
What are prognostic factors for local control and survival of female urethral cancer?
Location and extent of primary tumor
Treatment for female proximal urethral cancer
Anterior exent with PLND
Often multimodal therapy
Rad+Chemo(5-FU and MMC for SCC, MVAC for TCC) or Rad+surgery
What increases the likelihood of urethral cancer recurrence with a cutaneous diversion?
Prostatic stromal invasion
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