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5 Written questions

5 Matching questions

  1. Alloreactivity
  2. IL2
  3. Fab
  4. Differentiate between lymphoid and myeloid progenitor cells
  5. Discontinuous epitope
  1. a The recognition of non self MHC molecules by T-cells.
  2. b Lymphoid progenitor cells are the source of all Lymphocytes, they differentiate into T-cell, B-cells NK cells
    Myeloid progenitor cells are the source of all other WBC, they become neutrophil, basophil, eosinophil, dendritic, macrophage, mast cells.
  3. c An epitope consisting of amino acids from different parts of the sequence, brought together by folding. Also known as Conformational epitope.
  4. d Interleukin 2 is a cytokine that is produced by activated t cells it is essential for the proliferation of activated t cells and the development of an adaptive immune response
  5. e Fragment with Antigen Binding specificity, Photolytic fragment of IgG that contain the antigen binding sites.

5 Multiple choice questions

  1. Antigens that cause hypersensitive or allergic reactions, usually involving IgE antibody responses
  2. Derived from myeioid progenitor cells, Mast cells also secrete factors that attract and activate a special class of white blood cells called eosinophils which can kill certain types of parasites (eg intestinal worms) especially if the parasites are coated with IgE or lgA antibodies.
  3. The first stage of differentiation. The thymocytes do not have the CD3, CD4, CD8 or TCR surface markers that define t-cells.
  4. Immunoreceptor Tyrosine based Activation Motifs. These sequences allow the CD3 proteins to associate with cytosolic protein tyrosine kinases after receptor stimulation.
  5. Transporter Associated with antigen Processing. Degraded peptide fragments are transported into the ER through the dimerized TAP1 and TAP2.

5 True/False questions

  1. CentroblastNK cells are a subset of leucocytes capable of recognizing cell surface changes on virally-infected cells. NK cells bind to such infected cells and kill them. Also sometimes effective against transformed (tumor) cells.

          

  2. Germinal centreAreas in secondary lymphoid tissue that is a site of intense B-cell proliferation, maturation and death. They form around follicular dendritic cells.

          

  3. Affinity maturationThe first stage in type 1 allergic response. Allergen in exposed to person. Processed and presented to t-cells. Il's produced which act on b-cells to produce IgE activating mast cells.

          

  4. Components of C1 and their function areClassical - C5 combines with C2a, C3b and C4b complex then activated (splits) into C5a and C5b
    Alternative - binds with the Bb and 2 C3b complex then is activated into C5a and C5b

          

  5. Fas ligandExpressed on TH1 cells, when bound to Fas receptor cell induces apoptosis of macrophage to release contents.