5 Written questions
5 Matching questions
- Differentiate between lymphoid and myeloid progenitor cells
- Discontinuous epitope
- a The recognition of non self MHC molecules by T-cells.
- b Lymphoid progenitor cells are the source of all Lymphocytes, they differentiate into T-cell, B-cells NK cells
Myeloid progenitor cells are the source of all other WBC, they become neutrophil, basophil, eosinophil, dendritic, macrophage, mast cells.
- c An epitope consisting of amino acids from different parts of the sequence, brought together by folding. Also known as Conformational epitope.
- d Interleukin 2 is a cytokine that is produced by activated t cells it is essential for the proliferation of activated t cells and the development of an adaptive immune response
- e Fragment with Antigen Binding specificity, Photolytic fragment of IgG that contain the antigen binding sites.
5 Multiple choice questions
- Antigens that cause hypersensitive or allergic reactions, usually involving IgE antibody responses
- Derived from myeioid progenitor cells, Mast cells also secrete factors that attract and activate a special class of white blood cells called eosinophils which can kill certain types of parasites (eg intestinal worms) especially if the parasites are coated with IgE or lgA antibodies.
- The first stage of differentiation. The thymocytes do not have the CD3, CD4, CD8 or TCR surface markers that define t-cells.
- Immunoreceptor Tyrosine based Activation Motifs. These sequences allow the CD3 proteins to associate with cytosolic protein tyrosine kinases after receptor stimulation.
- Transporter Associated with antigen Processing. Degraded peptide fragments are transported into the ER through the dimerized TAP1 and TAP2.
5 True/False questions
Centroblast → NK cells are a subset of leucocytes capable of recognizing cell surface changes on virally-infected cells. NK cells bind to such infected cells and kill them. Also sometimes effective against transformed (tumor) cells.
Germinal centre → Areas in secondary lymphoid tissue that is a site of intense B-cell proliferation, maturation and death. They form around follicular dendritic cells.
Affinity maturation → The first stage in type 1 allergic response. Allergen in exposed to person. Processed and presented to t-cells. Il's produced which act on b-cells to produce IgE activating mast cells.
Components of C1 and their function are → Classical - C5 combines with C2a, C3b and C4b complex then activated (splits) into C5a and C5b
Alternative - binds with the Bb and 2 C3b complex then is activated into C5a and C5b
Fas ligand → Expressed on TH1 cells, when bound to Fas receptor cell induces apoptosis of macrophage to release contents.