5 Written questions
5 Matching questions
- Innate Immunity
- Mast cell
- MHC restriction
- Clonal expansion
- a When T-cell recognizes both peptide and MHC molecule, occurs during positive selection of T-cell maturation causing the T-cell to lose one of its two co-receptors CD4 or CD8.
- b The set of alleles carried on carried on a single chromosome. A person's haplotype is responsible for encoding MHC proteins.
- c Second line of defence non-adaptive/non-specific immunity. Involve the non-specific destruction of pathogens via macrophages, neutrophils, NK cells and circulating proteins of complement and acute phase proteins.
- d Proliferation of antigen triggered effector T-cells creating memory T-cells
Clonal expansion of activated B-cells leading to differentiation of progeny into antibody secreting plasma cells.
- e Derived from myeioid progenitor cells, Mast cells also secrete factors that attract and activate a special class of white blood cells called eosinophils which can kill certain types of parasites (eg intestinal worms) especially if the parasites are coated with IgE or lgA antibodies.
5 Multiple choice questions
- The recognition of non self MHC molecules by T-cells.
- Cell surface glycoprotein on T-cells that recognizes MHC1 on APC's
- A complement of proteins C1q, C1s and C1r. C1r and s are serine proteases. C1s can cleave the next proteins in the complement cascade C2 and C4.
- Fragment with Antigen Binding specificity, Photolytic fragment of IgG that contain the antigen binding sites.
- The classes of an immunoglobulins.
5 True/False questions
Sensitization → The coating of the surface of a pathogen or other particle with any molecule that make it more readily ingested by phagocytes. This is done through antibodies and the complement system
Type II hypersensitivity → Immediate type hypersensitivity response, antibody mediated IgE, soluble antigen, mast cell effector
Affinity maturation → The increase in affinity of the antigen-binding sites of antibodies for antigen that occurs during the course of an adaptive immune response. Is a result of somatic hypermutation in the Ig.
Opsonisation by Ig's → Opsonisation is the coating of the pathogen with Ig molecules for their preparation and identification for phagocytosis. There is no cross linking of Ig's
Ti antigen → When an immature B-cell binds soluble antigen, they are inactivated but not killed.