5 Written questions
5 Matching questions
- MHC restriction
- Fas ligand
- Pro-B cell
- a Natural variants of a protein that are encoded by the alleles of a given gene.
- b B cells in early development when they first express b cell marker proteins and it rearranges its heavy chain genes. D to J followed by V to DJ in late pro b phase.
- c When T-cell recognizes both peptide and MHC molecule, occurs during positive selection of T-cell maturation causing the T-cell to lose one of its two co-receptors CD4 or CD8.
- d Expressed on TH1 cells, when bound to Fas receptor cell induces apoptosis of macrophage to release contents.
- e Stimulated b-cells that are proliferating in the germinal centers.
5 Multiple choice questions
- Antigenic determinants or epitopes are specific regions of molecule that an antibody recognizes.
- Light chain the smaller of the two types of polypeptide chains that make up Ig. Molecule one constant region and one variable region.
- Opsonisation is the coating of the pathogen with Ig molecules for their preparation and identification for phagocytosis. There is no cross linking of Ig's
- Are co-stimulatory molecules induced by the breakdown of bacteria by macrophages or other APC's. Are expressed on APC's surface it interacts with the CD28 receptor on t-cells for t cell recognition
- The recognition of non self MHC molecules by T-cells.
5 True/False questions
Granzymes → When an immature B-cell binds soluble antigen, they are inactivated but not killed.
The components of C3 convertase → Classical - C5 combines with C2a, C3b and C4b complex then activated (splits) into C5a and C5b
Alternative - binds with the Bb and 2 C3b complex then is activated into C5a and C5b
IL2 → Cytokine secreted by TH1-cells to initiate proliferation and clonal expansion of B-cells.
Type I hypersensitivity → Immediate type hypersensitivity response, antibody mediated IgE, soluble antigen, mast cell effector
CD3 → Large signal transduction complex that is associated wit the T-cell receptor in the T-cell membrane. Contain Intracellular ITAMs domains.