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5 Written questions

5 Matching questions

  1. CD40
  2. Mast cell
  3. Anergy
  4. Main function of armed TH2 cells
  5. The components of C3 convertase
  1. a Co-stimulator expressed on macrophages. Binds to CD40 ligand on TH1 cells to activate macrophage to destroy intracellular contents.
  2. b Are proteolytic enzymes that are formed during complement activation to cleave C3 → In classical C4B and C2a. Alternative C3b and Bb, there by enabling covalently binding to antigens for targeting.
  3. c Derived from myeioid progenitor cells, Mast cells also secrete factors that attract and activate a special class of white blood cells called eosinophils which can kill certain types of parasites (eg intestinal worms) especially if the parasites are coated with IgE or lgA antibodies.
  4. d When an immature B-cell binds soluble antigen, they are inactivated but not killed.
  5. e Drive b-cells to differentiate and produce immunoglobulins of all other types. Also responsible for initiating B-cell responses by activating naïve B-cells to proliferate and secrete IgM. Leads to Humoral immunity.

5 Multiple choice questions

  1. The set of alleles carried on carried on a single chromosome. A person's haplotype is responsible for encoding MHC proteins.
  2. Expressed on TH1 cells, when bound to Fas receptor cell induces apoptosis of macrophage to release contents.
  3. Light chain the smaller of the two types of polypeptide chains that make up Ig. Molecule one constant region and one variable region.
  4. An epitope consisting of amino acids from different parts of the sequence, brought together by folding. Also known as Conformational epitope.
  5. Are serine esterases present in the granules of a cytotoxic t cells and NK cells. On entering the cytosole of the target cell granzymes induce apoptosis of the target.

5 True/False questions

  1. List the components of thymic cortexAre proteolytic enzymes that are formed during complement activation to cleave C3 → In classical C4B and C2a. Alternative C3b and Bb, there by enabling covalently binding to antigens for targeting.

          

  2. ProteasomesAre serine esterases present in the granules of a cytotoxic t cells and NK cells. On entering the cytosole of the target cell granzymes induce apoptosis of the target.

          

  3. B7Are co-stimulatory molecules induced by the breakdown of bacteria by macrophages or other APC's. Are expressed on APC's surface it interacts with the CD28 receptor on t-cells for t cell recognition

          

  4. Clonal expansionLight chain the smaller of the two types of polypeptide chains that make up Ig. Molecule one constant region and one variable region.

          

  5. CD44 domain co-receptor expressed on the cytokine secreting TH1 cells, contains the binding site for MHC2 on activated antigen presenting B-cells and macrophages.