5 Written questions
5 Matching questions
- Type I hypersensitivity
- Double negative thymocyte
- Opsonisation by Ig's
- Components of C1 and their function are
- a Opsonisation is the coating of the pathogen with Ig molecules for their preparation and identification for phagocytosis. There is no cross linking of Ig's
- b A complement of proteins C1q, C1s and C1r. C1r and s are serine proteases. C1s can cleave the next proteins in the complement cascade C2 and C4.
- c Large signal transduction complex that is associated wit the T-cell receptor in the T-cell membrane. Contain Intracellular ITAMs domains.
- d Immediate type hypersensitivity response, antibody mediated IgE, soluble antigen, mast cell effector
- e The first stage of differentiation. The thymocytes do not have the CD3, CD4, CD8 or TCR surface markers that define t-cells.
5 Multiple choice questions
- Lymphocyte Function Associated Antigen-1. An integrin expressed by all t-cells it is important for to allow for binding to cell adhesion molecules expresses on extracellular matrix.
- Areas in secondary lymphoid tissue that is a site of intense B-cell proliferation, maturation and death. They form around follicular dendritic cells.
- Are APC's. Involved in mediation of negative selection of T-cells, presenting processed epitopes via MHC ½, activation of naïve T-cells
- Second line of defence non-adaptive/non-specific immunity. Involve the non-specific destruction of pathogens via macrophages, neutrophils, NK cells and circulating proteins of complement and acute phase proteins.
- In Type II hypersensitivity, binding of a specific antibody directly to an antigen on the surface of a cell damages that cell either by cytolysis via the complement pathway or by destruction of cells by phagocytosis mediated by receptors for Fc or C3b.
5 True/False questions
Components of C5 convertase → Classical - C5 combines with C2a, C3b and C4b complex then activated (splits) into C5a and C5b
Alternative - binds with the Bb and 2 C3b complex then is activated into C5a and C5b
Fab → Lymphocyte Function Associated Antigen-1. An integrin expressed by all t-cells it is important for to allow for binding to cell adhesion molecules expresses on extracellular matrix.
ITAM → Immunoreceptor Tyrosine based Activation Motifs. These sequences allow the CD3 proteins to associate with cytosolic protein tyrosine kinases after receptor stimulation.
Junctional diversity → Hypervariable regions 1 and 2 of VH and VL chains are encoded in the VH and VL gene segments. Hypervariable region 3 falls at the junction of V/J gene segments in light chains and is partially encoded in the D segment in heavy chains. In both diversity at HV3 is increased by the addition/deletion of additional nucleotides during the joining process involved in gene rearrangement. This gives "junctional diversity" a further source of diversity in H and L chain variable regions.
Proteasomes → The classes of an immunoglobulins.