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5 Written questions

5 Matching questions

  1. Haplotype
  2. Innate Immunity
  3. Mast cell
  4. MHC restriction
  5. Clonal expansion
  1. a When T-cell recognizes both peptide and MHC molecule, occurs during positive selection of T-cell maturation causing the T-cell to lose one of its two co-receptors CD4 or CD8.
  2. b The set of alleles carried on carried on a single chromosome. A person's haplotype is responsible for encoding MHC proteins.
  3. c Second line of defence non-adaptive/non-specific immunity. Involve the non-specific destruction of pathogens via macrophages, neutrophils, NK cells and circulating proteins of complement and acute phase proteins.
  4. d Proliferation of antigen triggered effector T-cells creating memory T-cells
    Clonal expansion of activated B-cells leading to differentiation of progeny into antibody secreting plasma cells.
  5. e Derived from myeioid progenitor cells, Mast cells also secrete factors that attract and activate a special class of white blood cells called eosinophils which can kill certain types of parasites (eg intestinal worms) especially if the parasites are coated with IgE or lgA antibodies.

5 Multiple choice questions

  1. The recognition of non self MHC molecules by T-cells.
  2. Cell surface glycoprotein on T-cells that recognizes MHC1 on APC's
  3. A complement of proteins C1q, C1s and C1r. C1r and s are serine proteases. C1s can cleave the next proteins in the complement cascade C2 and C4.
  4. Fragment with Antigen Binding specificity, Photolytic fragment of IgG that contain the antigen binding sites.
  5. The classes of an immunoglobulins.

5 True/False questions

  1. SensitizationThe coating of the surface of a pathogen or other particle with any molecule that make it more readily ingested by phagocytes. This is done through antibodies and the complement system


  2. Type II hypersensitivityImmediate type hypersensitivity response, antibody mediated IgE, soluble antigen, mast cell effector


  3. Affinity maturationThe increase in affinity of the antigen-binding sites of antibodies for antigen that occurs during the course of an adaptive immune response. Is a result of somatic hypermutation in the Ig.


  4. Opsonisation by Ig'sOpsonisation is the coating of the pathogen with Ig molecules for their preparation and identification for phagocytosis. There is no cross linking of Ig's


  5. Ti antigenWhen an immature B-cell binds soluble antigen, they are inactivated but not killed.