5 Written questions
5 Matching questions
- MHC restriction
- Neutralization by Ig's
- a The first stage in type 1 allergic response. Allergen in exposed to person. Processed and presented to t-cells. Il's produced which act on b-cells to produce IgE activating mast cells.
- b Cytokine secreted by TH1-cells to initiate proliferation and clonal expansion of B-cells.
- c Are serine esterases present in the granules of a cytotoxic t cells and NK cells. On entering the cytosole of the target cell granzymes induce apoptosis of the target.
- d When T-cell recognizes both peptide and MHC molecule, occurs during positive selection of T-cell maturation causing the T-cell to lose one of its two co-receptors CD4 or CD8.
- e involves the Ig binding tightly to the pathogen to prevent interaction with it receptor on humans. The Ig's crosslink pathogens. The neutralized pathogen once bound is phagocytosed.
5 Multiple choice questions
- NK cells are a subset of leucocytes capable of recognizing cell surface changes on virally-infected cells. NK cells bind to such infected cells and kill them. Also sometimes effective against transformed (tumor) cells.
- Immediate type hypersensitivity response, antibody mediated IgE, soluble antigen, mast cell effector
- Large signal transduction complex that is associated wit the T-cell receptor in the T-cell membrane. Contain Intracellular ITAMs domains.
- Drive b-cells to differentiate and produce immunoglobulins of all other types. Also responsible for initiating B-cell responses by activating naïve B-cells to proliferate and secrete IgM. Leads to Humoral immunity.
- Stimulated b-cells that are proliferating in the germinal centers.
5 True/False questions
Fab → Lymphocyte Function Associated Antigen-1. An integrin expressed by all t-cells it is important for to allow for binding to cell adhesion molecules expresses on extracellular matrix.
Epitope → The classes of an immunoglobulins.
Double negative thymocyte → The recognition of non self MHC molecules by T-cells.
Innate Immunity → Second line of defence non-adaptive/non-specific immunity. Involve the non-specific destruction of pathogens via macrophages, neutrophils, NK cells and circulating proteins of complement and acute phase proteins.
IL2 → Cytokine secreted by TH1-cells to initiate proliferation and clonal expansion of B-cells.