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5 Written questions

5 Matching questions

  1. Type I hypersensitivity
  2. Double negative thymocyte
  3. CD3
  4. Opsonisation by Ig's
  5. Components of C1 and their function are
  1. a Opsonisation is the coating of the pathogen with Ig molecules for their preparation and identification for phagocytosis. There is no cross linking of Ig's
  2. b A complement of proteins C1q, C1s and C1r. C1r and s are serine proteases. C1s can cleave the next proteins in the complement cascade C2 and C4.
  3. c Large signal transduction complex that is associated wit the T-cell receptor in the T-cell membrane. Contain Intracellular ITAMs domains.
  4. d Immediate type hypersensitivity response, antibody mediated IgE, soluble antigen, mast cell effector
  5. e The first stage of differentiation. The thymocytes do not have the CD3, CD4, CD8 or TCR surface markers that define t-cells.

5 Multiple choice questions

  1. Lymphocyte Function Associated Antigen-1. An integrin expressed by all t-cells it is important for to allow for binding to cell adhesion molecules expresses on extracellular matrix.
  2. Areas in secondary lymphoid tissue that is a site of intense B-cell proliferation, maturation and death. They form around follicular dendritic cells.
  3. Are APC's. Involved in mediation of negative selection of T-cells, presenting processed epitopes via MHC ½, activation of naïve T-cells
  4. Second line of defence non-adaptive/non-specific immunity. Involve the non-specific destruction of pathogens via macrophages, neutrophils, NK cells and circulating proteins of complement and acute phase proteins.
  5. In Type II hypersensitivity, binding of a specific antibody directly to an antigen on the surface of a cell damages that cell either by cytolysis via the complement pathway or by destruction of cells by phagocytosis mediated by receptors for Fc or C3b.

5 True/False questions

  1. Components of C5 convertaseClassical - C5 combines with C2a, C3b and C4b complex then activated (splits) into C5a and C5b
    Alternative - binds with the Bb and 2 C3b complex then is activated into C5a and C5b

          

  2. FabLymphocyte Function Associated Antigen-1. An integrin expressed by all t-cells it is important for to allow for binding to cell adhesion molecules expresses on extracellular matrix.

          

  3. ITAMImmunoreceptor Tyrosine based Activation Motifs. These sequences allow the CD3 proteins to associate with cytosolic protein tyrosine kinases after receptor stimulation.

          

  4. Junctional diversityHypervariable regions 1 and 2 of VH and VL chains are encoded in the VH and VL gene segments. Hypervariable region 3 falls at the junction of V/J gene segments in light chains and is partially encoded in the D segment in heavy chains. In both diversity at HV3 is increased by the addition/deletion of additional nucleotides during the joining process involved in gene rearrangement. This gives "junctional diversity" a further source of diversity in H and L chain variable regions.

          

  5. ProteasomesThe classes of an immunoglobulins.