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5 Written questions

5 Matching questions

  1. MHC restriction
  2. Fas ligand
  3. Pro-B cell
  4. Allotype
  5. Centroblast
  1. a Natural variants of a protein that are encoded by the alleles of a given gene.
  2. b B cells in early development when they first express b cell marker proteins and it rearranges its heavy chain genes. D to J followed by V to DJ in late pro b phase.
  3. c When T-cell recognizes both peptide and MHC molecule, occurs during positive selection of T-cell maturation causing the T-cell to lose one of its two co-receptors CD4 or CD8.
  4. d Expressed on TH1 cells, when bound to Fas receptor cell induces apoptosis of macrophage to release contents.
  5. e Stimulated b-cells that are proliferating in the germinal centers.

5 Multiple choice questions

  1. Antigenic determinants or epitopes are specific regions of molecule that an antibody recognizes.
  2. Light chain the smaller of the two types of polypeptide chains that make up Ig. Molecule one constant region and one variable region.
  3. Opsonisation is the coating of the pathogen with Ig molecules for their preparation and identification for phagocytosis. There is no cross linking of Ig's
  4. Are co-stimulatory molecules induced by the breakdown of bacteria by macrophages or other APC's. Are expressed on APC's surface it interacts with the CD28 receptor on t-cells for t cell recognition
  5. The recognition of non self MHC molecules by T-cells.

5 True/False questions

  1. GranzymesWhen an immature B-cell binds soluble antigen, they are inactivated but not killed.


  2. The components of C3 convertaseClassical - C5 combines with C2a, C3b and C4b complex then activated (splits) into C5a and C5b
    Alternative - binds with the Bb and 2 C3b complex then is activated into C5a and C5b


  3. IL2Cytokine secreted by TH1-cells to initiate proliferation and clonal expansion of B-cells.


  4. Type I hypersensitivityImmediate type hypersensitivity response, antibody mediated IgE, soluble antigen, mast cell effector


  5. CD3Large signal transduction complex that is associated wit the T-cell receptor in the T-cell membrane. Contain Intracellular ITAMs domains.