5 Written questions
5 Matching questions
- Affinity maturation
- Memory cells
- a Transporter Associated with antigen Processing. Degraded peptide fragments are transported into the ER through the dimerized TAP1 and TAP2.
- b The increase in affinity of the antigen-binding sites of antibodies for antigen that occurs during the course of an adaptive immune response. Is a result of somatic hypermutation in the Ig.
- c General term for Lymphocytes that are responsible for immunological memory.
- d Cytokine secreted by TH1-cells to initiate proliferation and clonal expansion of B-cells.
- e 4 domain co-receptor expressed on the cytokine secreting TH1 cells, contains the binding site for MHC2 on activated antigen presenting B-cells and macrophages.
5 Multiple choice questions
- An epitope consisting of amino acids from different parts of the sequence, brought together by folding. Also known as Conformational epitope.
- When an immature B-cell binds soluble antigen, they are inactivated but not killed.
- Are serine esterases present in the granules of a cytotoxic t cells and NK cells. On entering the cytosole of the target cell granzymes induce apoptosis of the target.
- In Type II hypersensitivity, binding of a specific antibody directly to an antigen on the surface of a cell damages that cell either by cytolysis via the complement pathway or by destruction of cells by phagocytosis mediated by receptors for Fc or C3b.
- Antigens that cause hypersensitive or allergic reactions, usually involving IgE antibody responses
5 True/False questions
Epitope → Antigenic determinants or epitopes are specific regions of molecule that an antibody recognizes.
Alloreactivity → The recognition of non self MHC molecules by T-cells.
Mast cell → Derived from myeioid progenitor cells, Mast cells also secrete factors that attract and activate a special class of white blood cells called eosinophils which can kill certain types of parasites (eg intestinal worms) especially if the parasites are coated with IgE or lgA antibodies.
Isotype switch → A given variable region can be expressed with any of the different constant regions through a mechanism known as isotype switching. Is dependent on circulating cytokines.
Ti antigen → Thymus independent antigens. TI can elicit antibody production in the absence of t cells. TI-1 activates non-specific b cells. TI-2 have multiple identical epitopes that cross link b cell receptors.