29 terms

Animal Viruses

some class I, III, IV, V
Which classes of viruses can bring along there own RNA polymerase?
Which classes of viruses use Host Cell RNA Pol II?
Class I
Double-stranded DNA
(-) sense DNA used as mRNA template
Class II
Single Stranded DNA (-) or (+) sense
If (+) sense, dsDNA intermediate is made using Host cell DNA polymerase.
(-) sense DNA strand is used for mRNA template
Class III
Double-stranded RNA, (-) sense RNA strand is template for mRNA
Class IV
Single-stranded RNA, (+) sense, genome serves as mRNA
Class V
Single-stranded RNA, (-) sense, genome is template for mRNA
Class VI
Single-stranded RNA, (+) sense, genome needs to be converted into dsDNA and inserted into Host Genome. (-) sense strand of new DNA is then used as template.
What is the receptor for Poliovirus?
Sialic Acid
What is the receptor for influenza?
Direct entry
Only the genome is inserted into the cytoplasm
Receptor mediated endocytosis
Enveloped Viruses induces endocytosis. Lowered pH of Endosome results in the envelope of the virus from fusion with the Endosome Membrane.
Membrane Fusion
Virus the envelop fuses with host cell membrane, only capsid is inserted into the Cell
Non-structural Protein
Proteins that are made early
structural Protein
Proteins that are made later
Host Cell Polymerase
Most small Class I viruses use what for viral genome replication?
Virus Polymerase
Most large Class 1 Viruses use what for viral genome replication?
Host Cell RNA Pol II
Hepatitis B Virus use what for mRNA synthesis?
Virus Reverse Transcriptase
Hepatitis B Virus uses what for genome synthesis (dsDNA)?
Host Cell DNA Pol II
Class II Virus uses what for genome synthesis?
Animal Cells (Host) cannot make RNA use RNA template
Why do Class III, IV, V must bring their own RNA Pol or genes for RNA Pol, if they want to replicate their genome?
Icosahedral Capsids
Capsomer is packed as faces, and assembled into empty shell then genome insertion.
Helical Capsids
Capsomer is packed as lock washers, assembled around the genome.
Non-enveloped virus
Release is characterized by host cell lysis
Enveloped Virus, Budding
type of release where host nucleocapsid binding the Host cell membrane already equipped with the Env proteins.
Type of Release where virus buds through an internal cell membrane. Golgi or ER. Travels to Cell membrane via vessicles.
Hepatitis B Virus
Virus that uses Exocytosis release
HIV, Influenza
Viruses that use Budding release
Virus that uses Cell lysis for release