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most common nephrotic in kids

minimal change
foot process effaced
loss of albumin
triggered by recent inx/ immune prob
tx - steroids

granular pattern of IC; diffuse capillary thickening

membranous glomerulonephritis
spike & dome
due to drugs, inx, SLE, tumors

MCC adult nephrotic syndrome

membranous glomerulonephritis

granular patter of IC, hypercellular glomeruli

acute post strep glomerulonephritis

type 3 rxn
seen in kids

peripheral & periorbital edema & dark urine
hypercellular glomeruli

acute post strep glomerulonephritis

IgA, IgM, IgG, C3 deposited in mesangium

IgA nephropathy
related to Henoch-Schonlein dz

Kimmelstein Wilson lesions

nodular glomerulosclerosis

Diabetic glomerulonephropathy
due to nonenzymatic glycosylation of GBM

Nephrotic syndrome a/w HBV & HCV

membranoproliferative glomerulonephritis
tram trak appearance

nephrotic syndrome a/w HIV

focal segmental glomerulosclerosis

anti-GBM AB, hematuria, hemoptysis


subendothelial humps & tram track appearance

membrano-proliferative glomerulonephritis

nephritis, deafness, cataracts

Alport syndrome

Crescentic/rapidly progressive glomerulonephritis

cresent shaped, full of fibrin and plasma proteins.

Goodpastures - AB to GBM - linear IF
wegners granulomatosis - cANCA
microscopic polyangiitis- pANCA


type II

segmental sclerosis and hyalnosis

focal segmental

purpura on back and arms, IgA nephropathy


wire loop on LM

SLE nephropathy

apple green & congo red


spiking on GBM due to electron dense subepithelial depositis

membranoproliferative glomerulonephritis

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