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17 terms
Cancer Drugs
DNA Synthesis Inhibitors
Methotrexate
Permetrexed
Cytarabine
Fluorouracil
Gemcitabine
Permetrexed
Cytarabine
Fluorouracil
Gemcitabine
Methotrexate
MOA: Inhibits dihydrofolate reductase (DHFR)
A/E: Myelosuppression, Stomatitis, Renal and GI toxicity
A/E: Myelosuppression, Stomatitis, Renal and GI toxicity
Permetrexed
MOA: Inhibits DHFR, TS, GART
A/E: Myelosuppression, Hepatoxicity, GI toxicity
A/E: Myelosuppression, Hepatoxicity, GI toxicity
Cytarabine
MOA: Inhibition of DNA polymerase and incorparted into developing DNA
A/E: Nausea + Vomiting, Myelosuppression, Oral +GI ulceration
A/E: Nausea + Vomiting, Myelosuppression, Oral +GI ulceration
Fluorouracil
MOA: Converts to: d-UMP - inhibits thymidylate synthetase and prevents synthesis of thymidyline; 5-dUTP - interferes with RNA polymerase
A/E: Nausea + Vomiting, Myelosuppression, Oral + GI ulceration
A/E: Nausea + Vomiting, Myelosuppression, Oral + GI ulceration
Gemcitabine
MOA: S-phase specific inhibitor of DNA synthesis
A/E: Myelosuppression, Alopecia, Various GI disturbances
A/E: Myelosuppression, Alopecia, Various GI disturbances
DNA Alkylating Drugs
Cyclophosphamide
Cisplatin
Cisplatin
Cyclophosphamide
MOA: Cross-links DNA strands by forming covalent bonds betwwen alkyl groups of the drug and guanine bases of DNA
A/E: Myelosuppression, Alopecia, Hemorrhagic cystitis, Nausea + Vomiting
A/E: Myelosuppression, Alopecia, Hemorrhagic cystitis, Nausea + Vomiting
Cisplatin
MOA: Forms intrastrand and interstrand covalent bonds with DNA bases
A/E: Myelosuppression, Severe nausea + vomiting, Nephrotoxicity
A/E: Myelosuppression, Severe nausea + vomiting, Nephrotoxicity
Intercalating Drugs
Doxorubicin
Doxorubicin
MOA: Intercation of DNA but may also inhibit topoisomerase, and form of free radicals
A/E: Myelosuppression, Cardiac damage, Dose-dependent nausea + vomiting, mucosa ulceration
A/E: Myelosuppression, Cardiac damage, Dose-dependent nausea + vomiting, mucosa ulceration
Mitotic Inhibitors
Vincristine
Vinblastine
Paclitaxel
Vinblastine
Paclitaxel
Vincristine and Vinblastine
MOA: Block microtubule aassembly and interferes with mitosis
A/E: Vincristine - neurotoxicity, Vinblastine - myelosuppression
A/E: Vincristine - neurotoxicity, Vinblastine - myelosuppression
Paclitaxel
MOA: Block microtubule disassembly and interferes with mitosis
A/E: Neurotoxicity, Myelosuppression, Alopecia
A/E: Neurotoxicity, Myelosuppression, Alopecia
Topoisomerase Inhibitors
Etoposide
Irinotecan
Irinotecan
Etoposide
MOA: Inhibits topoisomerase II and prevents DNA replication
A/E: Myelosuppression, Nausea + Vomiting, Alopecia
A/E: Myelosuppression, Nausea + Vomiting, Alopecia
Irinotecan
MOA: Converted to active metabolite SN38 which inhibits topoisomerase I and prevents DNA replication
A/E: Myelosuppression, Nausea + Vomiting
A/E: Myelosuppression, Nausea + Vomiting