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thromboembolism, endometrial cancer risk, risk of bleeding with warfarin, osteoporosis, retinopathy, WG, HA
myelosuppression (DLT), leukopenia, hemorrhagic cystitis (clumps of blood in urine)
take on full stomach within 30 minutes of finishing a meal. Don't take with fruit juices. Both renally and hepatically eliminated.
dose adjustment in liver impairment, elevated bili. If giving with cisplatin, give this first
increased neutropenia with infusion, hypersensitivity, cardiac abnormalities, myalgia. Need to use cremophor
myocardial toxicity, LVEF needs to be monitored q3mo. Some injection site reaction, need to pretreat with Benadryl, dexamethasone, and/or epinephrine
can be used with 5FU (capecitabine too) for additive effect, synergistic effect with trastuzumab
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