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13 terms

Lymphomas + Leukemias

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Burkitt's Lymphoma
-Translocation?
-What gene?
-Histo morphology?
-Viral assocatin?
8;14
c-myc gene next to heavy-chain Ig

Starry-sky appearance
Sheets of lymphos + interspersed macrophages
EBV
Jaw lesion in endemic Africa
8;14
Burkitt's Lymphoma

Starry-sky appearance
Sheets of lymphos + interspersed macrophages
EBV
Jaw lesion in endemic Africa
Follicular lymphoma
'small cleaved-cell lymphoma'
14;18
bcl-2 - blocks apoptotis

WAXING + WANING LYMPHADENOPATHY
14;18
bcl-2
Follicular lymphoma = 'small cleaved-cell lymphoma'

WAXING + WANING LYMPHADENOPATHY
9;22
CML
Philadelphia chromosome
bcr-abl = tyrosine kinase = treat with imatinib

Myeloid stem cell = PMNs, basophils, etc.
Can accelerate and become ALL/AML
CML
9;22

Philadelphia chromosome
bcr-abl = tyrosine kinase = treat with imatinib

Myeloid stem cell = PMNs, basophils, etc.
Can accelerate and become ALL/AML
AML
Auer rods; DIC
15;17
all-trans retinoic acid (vitamin A)
15;17
AML
Auer rods; DIC
15;17
all-trans retinoic acid (vitamin A)
Mantle cell lymphoma
small UNcleaved cell lymphoma

11;14 - deactivation of bcl-1
CD5 - poor prognosis
11;14
Mantle cell lymphoma = small UNcleaved cell lymphoma

11;14 - deactivation of bcl-1
CD5 - poor prognosis
ALL
-Age?
-Markers?
-Triad of sx?
-Where can it spread?
YOUNG age
Can present with mediastinal mass in adults
Bone marrow replaced by lymphoblasts
TdT+ (marker of pre-T + pre-B cells)

IBA = infections (↓ WBC), bleeding (↓ platelets), anemia (↓ RBCs)

Can spread to CNS AND TESTES!
Hairy cell leukemia
Adults
MATURE B-cell tumor
TRAP+

(Don't confuse with smudge cell in CLL or reactive T-cell in EBV)
CLL
OLD people
Asymptomatic
SMUDGE cells
WARM hemolytic anemia (IgG)