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33 terms

dcstep1 - Leukemias/Lymphomas

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Mediastinal Lymphadenopathy
Hodgkin's Lymphoma
EBV association
Hodgkin's Lymphoma
Nodular Sclerosing
most common type of Hodgkin's Lymphoma
(lymphocyte predominant)
t(8;14)
Burkitt's Lymphoma
t(11;14)
Mantle Cell Lymphoma
t(14;18)
Follicular Lymphoma
c-myc activation
Burkitt's Lymphoma
cyclin D deactivation
Mantle Cell Lymphoma
bcl-2 expression
Follicular Lymphoma
Most common adult non-Hodgkin lymphoma
Diffuse Large B-Cell Lymphoma
HTLV-1
Adult T-Cell Lymphoma
CD4+
Mycosis Fungoides/Sezary Syndrome
monoclonal IgM spike
Waldenstrom's macroglubulinemia
(not Multiple Myeloma!)
it causes hyperviscosity, not bone problems
Rouleaux formation
Multiple Myeloma
"Fried Egg" cell on light microscopy
Plasma cell in Multiple Myeloma
"Clockface Chromatin"
Multiple Myeloma
t(12;21)
if found in ALL, signifies a BETTER prognosis
TdT+
ALL
CALLA+
ALL
warm antibody autoimmune hemolytic anemia
CLL/SLL (chronic/small)
tartrate-resistant acid phosphatase
Hairy Cell Leukemia
t(15;17)
AML (M3 subtype) aka Acute Promyelocytic Leukemia
Auer Rods
AML
Peroxidase-positive inclusions in granulocytes and myeloblasts. Treatment Drugs can cause rupture cells and release peroxidase, causing DIC!
Treated with all-trans retinoic acid (Vitamin A)
AML
Presents with DIC
AML
t(9;22)
CML
bcr-abl
CML
Molecular Signaling Mechanisms of...
c-myc
bcl-2
cyclin D
bcr-abl
look it up!
LOW leukocyte alkaline phosphatase
CML
"Blast Crisis"
CML turns into AML or ALL
t(11;22)
Ewing's Sarcoma
(non-lymph)
Age > 60 years
Chronic = CLL
Acute = AML
Age < 60 years
Chronic = CML
Acute = AML
(or hair cell possible)