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7 terms

Transmembrane Signaling

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ionotropic receptors (ligandgated channels)
Allow movement of ions across membrane
through a gate that opens when neurotransmitter
binds; mediate fast behavior
"metabotropic" receptors
Involved in signal transduction cascades: Alter internal chemistry, Can modulate ion channels, Can result in alteration of protein synthesis via effects on gene transcription
Most common type is the G protein-coupled receptor
Couples a neurotransmitter (1st messenger) to an
effector protein via a G Protein (guanosine
phosphate binding protein) attached to the receptor
second messenger (G-protein coupled receptor)
can activate other enzymes resulting in a
transduction cascade that can affect many chemical
reactions
gene transcription
change in production of proteins; Formation of new receptors, enzymes, trophic
factors
Nuclear hormone receptors
bind to steroids (corticosteroids, mineralcorticoids, sex steroids, vitamin D), thyroid hormone
Activated tyrosine kinase receptor
Results in gene transcription