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6 terms

Drugs affecting urinary output

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Hydrochlorothiazide
Increases excretion of Na, Chl, K+, and water. May reduce GFR. Should not be used if pt has preexisting renal disease. Treats HTN and edema. S/E: dizziness, lightheadedness, vertigo, N/V, & anorexia. Most common: orthostatic hypotension. Electrolyte changes: hypokalemia, hyponatremia, hypochloremia, and hypercalcemia. Hyperglycemia, increased uric acid. Monitor BP, P, weight, I&O, potassium. Weak diuretic.
Lasix (furosemide)
Excretes Na, Chl, K+, and water. STRONG diuretic. Treats edema from CHF, pulmonary edema, hepatic & renal disease. May be used to treat HTN, especially if hx of renal disease. May cause greater loss of K+. Encourage diet high in K+ or use supplements. Do NOT use if sulfa allergy. Ototoxicity if admin too fast. No more than 10 meq/hr for K+.
Triamterene (Dyrenium)
Promotes Na & water excretion, & reabsorption of K+. Weak by itself, synergistic with other diuretics. Can cause hyperkalemia; high risk in older adults.
Mannitol (Osmitrol)
Draws water into vascular space via osmosis. Allows diuresis. Treats acute renal failure, increased ICP, increased IOP. Adverse effects: May initially induce fluid overload, crystalizes easily - warm water and use filter tubing.
Acetazolamine (Diamox)
Increases loss of Na, K+, bicarbonate, and water. Prevents formation of aqueous humor and decreases IOP. Primarily treats chronic, open angle glaucoma.
Tolterodine (Detrol)
Treats overactive bladder, urinary frequency, and urge incontinence. Adverse effects: dry mouth, HA, and urinary retention.