Increases excretion of Na, Chl, K+, and water. May reduce GFR. Should not be used if pt has preexisting renal disease. Treats HTN and edema. S/E: dizziness, lightheadedness, vertigo, N/V, & anorexia. Most common: orthostatic hypotension. Electrolyte changes: hypokalemia, hyponatremia, hypochloremia, and hypercalcemia. Hyperglycemia, increased uric acid. Monitor BP, P, weight, I&O, potassium. Weak diuretic.