What are the 2 major types of Ach muscarinic R's and where are they?
-M2:heart, causes decr adenyl cyclase, decr cAMP, K channel opens, K in, hyperpolarize, decr HR
-mimics vagal activity
-causes decr in heart contraction (even though will incr HR w/ low dose)
-M3:Everywhere, causes incr PLC, incr IP3 & DAG, ca enters cell, rel of vessicles w/NT
-on BV's, causes vasodilation via NO
-respiratory tract, causes bronchoconstriction & increase in secretions