Nervousness, emotional lability, sweating, heat intolerance, tremors, dyspnea, palpations, exacerbation of angina pectoris, weight loss, frequent BM, proximal muscle weakness, oligomenorrhea. Restless, anxious, warm, velvety skin, palmar erythema, onycholysis, tremor, fingers and tongue, stare, lidlag, fine silky hair, tachyarrhythmias, systolic murmurs, extreme thyrotoxicosis (thyroid storm). Ablation with radioiodine, most common in US, can lead to hypothyroidism (treat with T4), antigen leak will cause autoimmune exacerbation of eye disease, prevented by prednisone for 1mo. Surgery-preceeded with iodine, more agressive, last resort. Carbimazole drugs: most common in Japan, 50% effective after 2 years (then can do surgery if no other choice), immunosuppression (neutropenia/leukopneia, vasculitis/severe arthritis), discontinue use. Selenium sometimes used.