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sub-cortical dementia: progressive supranuclear palsy
Terms in this set (18)
which dementia is consider the "prototypical subcortical dementia?
PSP, because it help to bring to create the category of subcortical dementia
Whats the age onset of PSP and survival rate of PSP?
PSP is mostly a geriatric rare disease with a mean=65 age onset and a median survival of 6 years
How do we differentiate btw PSP and PD
Due to its similar symptoms, PSP is commonly misdiagnosed as PD, but if give PD treatment (L-DOPA) to PSP patients it wont work
Which parts of the brain does PSP affects and what symptoms does it cause?
-Subthalamic nuclues: Motor/visual disturbance
-Subtantia nigra: Motor deficits
-superior colliculus: Visual disturbance
-inferior colliculus: attention focus to auditory stimuli
-striatum: cognitive deficits
what are 2 of the classic symptom of PSP?
Vertical gaze palsy/down gaze abnormalities and we see greater impairment of Executive/prefrontal functions
Conjugate gaze palsies
-neurological disorders affecting the ability to move both eyes in the same direction. These palsies can affect gaze in a horizontal, upward, or downward direction
PSP Motor symptoms
-gait impairment (slowed wide based)
-rigidity and/or resting tremo
-postural instabillity with falling down (backwards)
-Downward gaze abnormalities
PSP Dementia syndrome
-personality changes like apathy and depression
an inability to control the muscles in the face; impacts a person's ability to speak and swallow; also causes uncontrollable crying or laughing at inappropriate times. Mostly unilateral
PSP Cognitive symptoms
-Prefrontal/executive (disproportionately impaired)
-Poor orientation knowledge of place in time
-Slowed or impaired reasoning, much more than PD
characterize extreme dependency on prototypical responses
Inability to stick to a task, often leaves without finishing. Ex: Goals, sentences etc
PSP cognitive symptoms: Language
-Processing and comprehension relatively spared
difficult or unclear articulation of speech that is otherwise linguistically normal.
PSP cognitive symptoms: Memory
-Mildly impair, complain of forgetfulness
-Retrieval is more impair than recognition
What is the physiological brain hallmark of PSP?
"Pinguin sign" in the midbrain, on top of the pons
No effective treatment exist. Dopaminergic agents help some patients, but most are not. Main goal is to monitor the progress of the disease
Difference btw PD and PSP
-Atrophy of substantia nigra
-mild/moderate Executive dysfunction
-usually responsive to L-DOPA
-atrophy of several subcortical areas
-severe executive dysfunctions
-poor response to drug therapies
-downward gaze palsy
THIS SET IS OFTEN IN FOLDERS WITH...
sub-cortical dementia: Huntington's Disease
sub-cortical dementia: Creutzfeldt-Jakob disease
Visual system and language
Disorders of memory
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