Salicylate. Nonopioid analgesic. Contraindicated in GI bleeding, bleeding disorders, younger than 12 years (due to risk of Reye's syndrome), children/teens with flu-like syndromes, pregnancy/lactation, with vitamin K deficiency, PUD, anemia, renal or hepatic dysfunction. Side effects include increased bleeding time, drowsiness, dizziness, confusion, h/a, hallucinations, heartburn, anorexia, rash, urticaria, bruising, tinnitus, seizures, coma, GI bleeding, hepatitis, and Reye's syndrome. Nursing considerations: Dosage dependent upon age of patient & condition being treated. GI upset may be decreased by giving with full glass of water, milk, food or an antacid. Administer at least 30 minutes prior to PT or planned activity to minimize discomfort. Report any signs/symptoms of hepatic/renal toxicity Report visual changes, tinnitus, allergic reactions, and bleeding. Do not exceed recommended dosage. Avoid alcohol to reduce chance of GI bleeding. Interact with antacids, urinary alkalizers, anticoagulants, alcohol, corticosteroids, warfarin, insulin, thrombolytic agents, penicillins, phenytoin, valproic acid, oral hypoglycemics, sulfonamides, ammonium chloride, urinary acidifiers, nizatidine, probenecid, spironolactone, NSAIDs, beta blockers, ginger, & caffeine.