Create an account
Max effect that drug can produce
Increased = higher relative response
Equal curve heights = work on same receptor
Moderate efficacy partial agonist
Act as agonists with low & moderate sympathomimetic activity (moderate heart failure)
Act as antagonists with high sympathomimetic activity (severe heart failure)
Fraction of administered drug that reaches the systemic circulation
Key in determining onset of drug action
Volume of distribution definition
Apparent volume of body fluid that drug appears to distribute into to produce a drug [ ] equal to that in blood
Type of drugs that are most affected by changes in protein binding
Highly bound (>90%)
Drug redistribution effects
Changes drug action via redistribution to low-perfusion tissues (sk m, fat)
Significant routes of elimination
Renal (GFR dep on size <40kDa, charge, protein binding - drugs not bound cleared at creatine rate)
Hepatic (via bile), exhalation
First order kinetics
Fixed FRACTION of drug metab/unit time
Most drugs, amount metabolized proportional to drug [ ]
Functionalization reactions that introduce or expose a functional group on parent compound (eg oxidation)
Dealkylation (N-, O-, S-)
Glucuronidation (high capacity)
Sulfation (low capacity)
Acetylation (variable capacity)
Please allow access to your computer’s microphone to use Voice Recording.
Having trouble? Click here for help.
We can’t access your microphone!
Click the icon above to update your browser permissions and try again
Reload the page to try again!Reload
Press Cmd-0 to reset your zoom
Press Ctrl-0 to reset your zoom
It looks like your browser might be zoomed in or out. Your browser needs to be zoomed to a normal size to record audio.
Please upgrade Flash or install Chrome
to use Voice Recording.
For more help, see our troubleshooting page.
Your microphone is muted
For help fixing this issue, see this FAQ.
Star this term
You can study starred terms together