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54 terms

Path - Neoplasia/2

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What is the term for 'new growth'? 'undergone heritable genetic changes'?
Neoplasia, Neoplasm
What are the 2 basic components of neoplasms?
parenchyma, stroma
What is the term for formation and development of collagen-rich fibrous tissue? example?
desmoplasia; scirrhous carcinoma
What are 3 preneoplastic changes?
hyperplasia, metaplasia, dysplasia
What are the 2 neoplastic changes?
metaplasia, dysplasia
What is the term for when specialized epithelium is replaced by less specialized epithelium? reversible?
metaplasia; yes
What are 2 causes of epithelial metaplasia?
chronic irritation, vit A deficiency
What is the term for when the entire thickness of the epithelium is replaced by dysplastic cells?
carcinoma in situ
Is there preservation of the basement membrane in carcinoma in situ?
yes
What is the suffix of benign mesenchymal tumors? malignant mesenchymal tumors?
oma; sarcoma
What is the origin on mesenchymal tumors?
mesodermal
Which 2 cells lead to epithelial tumors?
endodermal, ectodermal
What is a benign epithelial tumor that projects from a mucosal surface?
polyp
when naming malignant tumors, what 4 things do you add?
organ, epithelium or gland structures, induces desmoplasia, produces mucin
What are mammary tumors, teratomas and nephroblastomas examples of?
mixed tumors
What germ cells do teratomas arise from?
totipotential
Which types of tumors have a mixture of adult and embryonic tissues?
teratomas
What is another term for undifferentiated/lack of differentiation?
anaplastic
What are the 4 characteristics of anaplasia?
pleomorphism, abnormal nucleus, high mitotic rate, loss of polarity
What are the 3 types of spread of malignant tumors?
transcoelomic, lymphatic, hematogenous
What is the term for the seeding of body cavities and surfaces?
transcoelomic
What are the steps of the metastatic cascade? 4
loss of caderin, integrin bind to ECM, degradation of BM and ECM, migration stimulated by autocrine GF
What is the term for progressive accumulation of heritable changes in tumor cells?
tumor heterogeneity
What is generated during tumor heterogeneity?
subclones
Which type of neoplasia infiltrate the gastric wall and spread throughout peritoneum?
gastric carcinomas
Which stain do you use to diagnose mucinous gastric carcinoma?
Alcain blue/PAS
What is the incidence of age-adjusted cancer in dogs and humans? (per 100,000)
381
What 3 things are observed in tumor cells?
DNA mutations, epigenetic changes, chromosomal alterations
What are the 3 steps of tumor development?
initiation, promotion, progression
How is a tumor formed?
clonal expansion of single precursor cell with genetic damage
What are the 4 classes of normal regulatory genes?
proto-oncogenes, tumor suppuressor, apoptosis, DNA repair
Which gene acts as a molecular policeman when facing damage to the genome?
p53
What are the 7 changes in cell physiology that together determine malignant phenotype?
growth signals, apoptosis evasion, DNA repair defect, limitless replicative potential, angiogenesis, invade/metastasize, escape immunity
What can tumor Ag be used for? 3
diagnosis, monitoring, immunotherapy
What are the major immune defense mechanism against tumors?
CD8+
What are the secondary immune defense mechanisms against tumors? 2WBC, 1 cytokine
NKC, MO, IFN-g
What activates MO?
IFN-g
what causes dimerization, protein cross-links in DNA molecules, formation of cholesterol alpha oxide?
UV radiation
What is the term for an indirect and remote effect that is caused by tumor cell products that cause unexplained symptoms in cancer patients?
paraneoplastic
What is the most frequently observed paraneoplastic syndrome - esp in dogs?
hypercalcemia of malignancy
What is hypercalcemia of malignancy due to?
production of calcemic humoral substances
What is the calcemic humoral substance produced during hypercalcemia of malignancy?
PTHRP
Is hypercalcemia due to osteolysis by skeletal metastases a paraneoplastic syndrome?
no
What are the 6 signs of hypercalcemia?
weakness, arrhythmia, anorexia, vomiting, renal failure, pupd
What 4 things besides tumors cause hypercalcemia?
hyperparathyroidism, renal failure, hypoadrenocorticism, hypervitaminosis D
What 2 things is hypertrophic pulmonary osteopathy known as?
Marie's Disease
What is the disease: multiple benign cutaneous lesions with bilateral renal disease?
nodular dermatofibrosis
What are the 3 things caused by underlying bilateral renal disease?
polycystic kidneys, renal cystadenomas/ cystadenocarcinomas
What is used to diagnose tumors?
immunohistochemistry
delete
yes
How are tumors graded?
I to IV
What is involved with tumor staging?
size of pimary tumor, spread to ln, hematogenous metastases
What is the system of staging?
TNM
What does T stand for? N? M?
primary tumor, LN involvement; blood borne metastases