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What is 1 + 3?
Diseases of Immunity
ANY ROUND CELL WITH RATHER DENSE STAINING CYTOPLASM AND MINIMAL CYTOPLASM IN CONNECTIVE TISSUE, A BIT BIGGER THAN AN RBC,
Killing infected cell
Stimulate B lymphocyte, inflammation, activation of macrophages
Common lymphoid progenitor to small lymphocyte (which can turn into B lymphoctyte...need IL 1,2,4,6,7 to become a T lymphocyte).
Megakaryocyte to thrombocytes
Granulocyte-macrophage colony-stimulating factor (GM-CSF)
Common myeloid progenitor to myeloblast to basophil, neutrophil, esoinophil, monocyte
Natural Kill cell made in Bone Marrow
Plasma Cell production in the bone marrow
T cells made
Structure of T Cell Receptor
disulfide-linked heterodimer made up of an α and a β polypeptide chain, CD3 complex, zeta chain dimer
specificity of T cells for peptides displayed by the cell surgace MHC molecules
Aids T cell ratio
CD4 : CD8 is .5:1 instead of 2:1 ratio.
Signals needed for T Cell Activation
1. TCR + MHC & CD4/8 + MHC
2. CD 28 on T Cell + B7-1 (CD80)/ B7-2 (CD 86)
T cells proliferate
What does CD 4 TH1 cell secrete?
IL 2 and IFN gamma. Activate macrophages and type IV hypersensitivity.
CD4 TH 2 cell secretion
IL 4, IL 5, IL 13. Type I hypersensitivy & Eosinophils
Ig alpha, Ig beta, IgM, IgD, CD 28
B cell receptor
CR2, CD 21
Type 2 complement receptor B lymphocyte, receptor for the Epstein- Barr Virus (Ebv readily infects B cells)
ANY CELL MIXED IN WITH LYMPHOCYTES BUT HAS A LARGER MORE "OPEN", LESS DENSE, LESS CIRCULAR NUCLEUS WITH MORE CYTOPLASM IS A