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21 terms

Diseases of Immunity

STUDY
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ANY ROUND CELL WITH RATHER DENSE STAINING CYTOPLASM AND MINIMAL CYTOPLASM IN CONNECTIVE TISSUE, A BIT BIGGER THAN AN RBC,
LYMPHOCYTE
Antibody secretion
Plasma Cell
Killing infected cell
CD 8
Stimulate B lymphocyte, inflammation, activation of macrophages
CD4
FLT-3 ligand
TNF-a
TGFβ
Common lymphoid progenitor to small lymphocyte (which can turn into B lymphoctyte...need IL 1,2,4,6,7 to become a T lymphocyte).
Tpo= Thrombopoietin
Megakaryocyte to thrombocytes
Epo= erythropoietin
Erythrocyte
Granulocyte-macrophage colony-stimulating factor (GM-CSF)
Common myeloid progenitor to myeloblast to basophil, neutrophil, esoinophil, monocyte
IL 15
Natural Kill cell made in Bone Marrow
Flt 3L
Plasma Cell production in the bone marrow
IL 7
T cells made
Structure of T Cell Receptor
disulfide-linked heterodimer made up of an α and a β polypeptide chain, CD3 complex, zeta chain dimer
MHC Restriction
specificity of T cells for peptides displayed by the cell surgace MHC molecules
Aids T cell ratio
CD4 : CD8 is .5:1 instead of 2:1 ratio.
Signals needed for T Cell Activation
1. TCR + MHC & CD4/8 + MHC
2. CD 28 on T Cell + B7-1 (CD80)/ B7-2 (CD 86)
IL 2
T cells proliferate
What does CD 4 TH1 cell secrete?
IL 2 and IFN gamma. Activate macrophages and type IV hypersensitivity.
CD4 TH 2 cell secretion
IL 4, IL 5, IL 13. Type I hypersensitivy & Eosinophils
Ig alpha, Ig beta, IgM, IgD, CD 28
B cell receptor
CR2, CD 21
Type 2 complement receptor B lymphocyte, receptor for the Epstein- Barr Virus (Ebv readily infects B cells)
ANY CELL MIXED IN WITH LYMPHOCYTES BUT HAS A LARGER MORE "OPEN", LESS DENSE, LESS CIRCULAR NUCLEUS WITH MORE CYTOPLASM IS A
Macrophage