Decrease in platelets.
Result of activation of nociceptors pain fibers deep in cutaneous tissue.
Arises from bone joint or connective tissue; well localized gnawing sensation.
Result of nociceptor activation in thoracic or abdominal tissue; can be pancreas, liver, GI poorly localized... cramping.
screen entire population (PKU)
Selective or Prescriptive Screening
high risk populations (BRCAI, sickle cell)
looking for defect or condition. (BP check)
2 or more defects or conditions; school vision and hearing.
screening over time; height, Denver Developmental Screening Test.
21 years of 3 years post inter
values or rules based on a clients conscience. Serve as guide to right/wrong behavior.
From Greek word Ethos, means conduct, customs and character. A process of deciding best course of action when faced with conflict.
Data and Saftey Monitoring Board
Reports to IRB, monitors client safety in large clinical trials.
Institut. review board
Phase 1 Clinical Trials
Assist in developing safe drug levels and schedules of new drug using human subjects.
Phase 2 Clinical Trials
Usually focus of particular type of cancer, study safety and effect of drug on human body.
Phase 3 Clinical Trials
Compare new drug with standard therapy; usually large number of participants.
Phase 4 Clinical Trials
Long term safety and effectiveness; large number of participants needed.
Genetic portion of DNA that regulates normal cell growth. Promote cell division
Tumor Supressor Genes
Genetic portion of DNA that stops, inhibits, or supersede cell division.
Is most common mutated tumor suppressor gene.
failure of _________ may lead to malignancy.
Altered forms of normal proto-oncogenes. May give rise to cancers.
process of transmitting information received on the cell membrane to the cell's nucleus.
Overproduction of RAS oncogenes have been identified in what cancers?
Pancreatic, colorectal, lung, and thyroid.
cells divide, increase bulk, and secrete enzymes. Invade surrounding tissues.
Ability of tumor to grow new blood vessels.
Spread of primary tumor to distant sites.
Inherited Cancers occur via...
carcinogenic mutation in germ cells. Account for 10% of cancer in the USA
does not mix with ASA or NSAIDS; increases risk of methotrexate toxicity.
Combination therapies that include etoposide and alk. agents...
cause increase FSH levels and azoospermia or olgiospermia in 30-40% mals. Test funct. may be normal if tx with etoposide and nonalkylating agents (vincrustine, doxorubiein)
Warm Pack Plant Alkaloids. Cold- all other chemos
only lab increase in DIC is D-Dimer and FDP titers; everything else decrease.
too much ADH mostly from pituitary gland.
causes water to be reabsorbed instead of excreted through the kidneys.
High concentrate sodium IVF
T=>100x4, P>90, Resp>20, WBC> 12,000
during cell kill. Give IVF
Lead time bias
cancer detected early but does not affect survival.
whole lung removed
small wedge near lung surface
removal of 1 or more segments of lung
removal of lobe of lung
granulocyte stimulating factor- stimulates myloid line; increases WBC's; starts 24 hours post chemo for 3-14 days.
long acting G-CSF
most common cause of death in person with cancer.
Very high Emetogenic
Cisplat, Cytoxan, Melphalan
Barbo, Cisplant, Etoposiac, Irinotecan, Oxaliplatin, Doxrubicin
Vinoustine; age less than 50 risk for N+V (may have more anticiporty nausea)
Ibuprofen use caution in...
Increased risk DIC
leukemia, lymphoma, buliany, breast, colon, gastric, lung, pancreatic, prostate, melanoma
cytokine, based on the bodys own cytoxic response. Flu like symptoms, fever and chills.
jerking R/+ drg metabolites -->switch drug!
oral cane. brush 90 seconds bid
etoposide, cytoxin = azoospermia 30-40%post-pubertal men
Interferon, Interleukin + Vanc
Can produce a fever
90% of all bowel obstruction occur in...
the small intestine (think: small- can't get through!)
pred- may need stool softeners
removes all reproductive organs + adjacent tissues; involves colon, bladder, ureters, and other organs. Freq requires colostomy and urostomy.