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Antilipemics

Terms in this set (11)

Chylomicrons
large particles that transport fatty acids and cholesterol to the liver mostly composed of triglycerides
LDL
stick to blood vessel walls and form plaque so there is a small area for blood to get by- plaque can break off and form a heart attack or stroke
HDL
mate with LDL and carry them out of the blood stream then there is no plaque sitting in the blood vessels

with very high HDL, may have the ability to never have any cholesterol
Hyperlipidemia
antilipemics

continue with diet and exercise changes
antilipemics prescribed based on lipoprotein phenotype
Bile Acid Sequestrates
Questran and Colestid

powder medication

resin that binds with bile acids in the intestine

constipation and peptic ulcer formation

take with fluids, must mix with water or juice to prevent constipation
Fibric Acid Derivatives
Atromid-S and Lopid

Reduce triglyceride and VLDL

many side effects

do not give w anticoagulants, highly protein bound

not suggested for long term use

t1/2: 1.5hr
Niacin (Vit B2)
Reduces LDL and VLDL

Need very high dose to be effective

poor tolerance due to SE and requires a large dose

SE- GI disturbances, abnormal liver function, flushing, hyperglycemia, hyperuricemia
Vastatins and Statins
HMG coA reductase inhibitors

"miracle drug of cholesterol"

inhibit cholesterol synthesis n the liver

decreases cholesterol and LDL and raises HDL slightly

2-3 weeks for results
Examples of Vastatins and Statins
zocor, lescol, pravachol, lipitor, mevachor
SE of Vastatins and Statins
GI disturbances, ha, muscle cramps, tiredness
Rhabdomylosis
watch for muscle tenderness or weakness should be promptly reported with vastatins and statins

elevation in cardiac muscle enzymes
THIS SET IS OFTEN IN FOLDERS WITH...