Upgrade to remove ads
Indirect acting parasympathomimetics
Terms in this set (31)
What is meant by "indirect acting"?
*can be reversible or irreversible
How do indirect parasympathomimetics works?
-they have muscarinic and nicotinic effects via
-cholinesterase breaks down Ach; when it is inhibited, there is more Ach present; acts as a cholinergic agonist
-may have direct nicotinic effect on neuromuscular junction (secondary effect)
What type of drugs are indirect-acting parasympathomimetics?
*reversible or irreversible cholinesterase inhibitors
Reversible cholinesterase inhibitors:
Irreversible cholinesterase inhibitors:
-ectoparasiticides and insecticides
What kind of compound is physostigmine?
-a tertiary amine (good penetrator of membs)
What is physostigmine commonly used for?
-as an opthalmic agent to treat open-angle glaucoma
Should physostigmine be used for closed-angle glaucoma?
NO, it may aggravate it
For which patients should you use physostigmine with extreme caution?
those with seizures bc it can **cross the BBB (good penetrator)
What does physostigmine counteract?
-many central and peripheral effects of anticholinergic drugs (parasympatholytics/cholinergic antagonists) such as atropine
-and is used for Datura spp poisoning
How is physostigmine administered?
-parenterally (IV or IM)
*for overdose/poisoning of atropine
-topically on the eye
Duration of action for physostigmine:
IV: 1-2 hours
after opthalmic use: 12-36 hours
What kind of compound is neostigmine?
-a quaternary amine parasympathomimetic (indirect acting cholinergic agonist)
What is neostigmine used for?
-to antagonize the effects of non-depolarizing muscle relaxants (tubocurarine)
-causes sk mm contraction
*antidote for curare-like drugs
What clinical disease is neostigmine associated with?
-treatment and diagnosis of myasthenia gravis
What else is neostigmine used for?
-as a prokinetic to stimulate GIT motility
-to treat postoperative non obstructive urinary retention (like bethanechol) to cause urination
How is neostigmine administered?
orally and parenterally
Neostigmine has a longer duration of action than which drug?
What kind of compound is edrophonium?
-a quaternary amine (like neostigmine)
What disease is associated with edrophonium?
-it is the drug of choice for
MG, but NOT for treating it
How is edrophonium administered?
Edrophonium onset and duration of action:
-short duration of action
*neostigmine has a longer duration of action than edrophonium
What is an advantage of edrophonium's short duration of action?
-less adverse side effects
What type of compound is pyridostigmine?
-a quaternary amine
What disease is pyridostigmine used to treat?
*pryidostigmine is preferred for treatment of MG
How is pyridostigmine administered?
Duration of action of pryidostigmine:
longer than neostigmine
Which drug is used to treat toxicity of cholinesterase inhibitors (indirect-acting parasympathomimetics)?
What kind of compound is demecarium?
-a carbamate reversible cholinesterase inhibitor (indirect acting parasympathomimetic)
What is demecarium used for?
-topical opthalmic miotic (pupil constriction) agent
-used for open-angle glaucoma
Duration of action of demecarium:
as long as opthalmic organophosphates: 12-48 hours
THIS SET IS OFTEN IN FOLDERS WITH...
Chapter 33 review
Pharmacology Final Exam
YOU MIGHT ALSO LIKE...
Autonomics Drugs and Diseases
Drugs Used in the Treatment of GI Disorders
Asthma - Respiratory Drugs
OTHER SETS BY THIS CREATOR