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Rh antigen on RBC surface. Rh-mother exposed to fetal Rh+ blood (often during delivery) may make anti-Rh IgG that can cross placenta during subsequent pregnancies and ause hemolytic disease of the newborn (erythroblastosis fetalis) in the next fetus that is Rh+. Treatment: Rho (D) immune globulin (rhogam) for the mother at first delivery to prevent future erythroblastosis
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