necrotic cells release uric acid, ATP, DNA which induce inflammation
How does hypoxia induce inflammation?
via hypoxia-induced factor- 1a
What is hypoxia-induced factor-1a?
released by cells deprived of O2 activating the transcription of many mediators involved in inflammation - VEGF
What is the function of VEGF?
known to increase vascular permeability
How is inflammation induced by immune reactions?
- hypersensitivity reactions - cytokines for t cells
What is stimulated with inflammation?
innate immune system
What is the innate immune system?
non-specific defense for environmental stimuli
What are the 4 components of the innate immune system?
- physical barriers and microenvironments - molecular products from mucosal epithelia - preformed and synthesized chemical mediators from tissue effector cells - effector molecules in the blood like plasma proteases and in certain nerve fibers
What are the physical barriers and microenvironments that make up the innate immune system?