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42 terms

First Aid Pharm - Psych

STUDY
PLAY
Social phobias
SSRI
Atypical depression
MAOI, SSRIs
Depression
SSRIs, SNRIs, TCAs
Bipolar
Lithium, valproic acid, carbamazapine
Depression with Insomnia
Trazodone, Mirtazapine
OCD
SSRIs, Chlomipramine
Anxiety
Benzodiazepines, Buspirone, SSRIs
Schizophrenia
Antipsychotics (have excess dopamine)
Tourettes
Antipsychotics (haloperidol, resperidone)
Antipsychotics MOA
D2 receptor blocking
Side effects
Neuroleptic malignant syndrome, Extrapyramidal symptoms, galactorhhea; muscarinic alpha and histamine blocking effects
Neuroleptic Malignant syndrome (NMS)
Rigidity, myoglobinuria, ANS instability, pyrexia

"FEVER" - Fever, Encephalopathy, Vitals unstable, Elevated enzymes, Rigidity of muscles
Treatment for NMS
Dantrolene or dopamine agonists (bromocriptine)
Evolution of Extrapyramidal symptoms
4 h acute dystonia, 4 d akinesia (Parksinsonian Sx), 4 wk akathisia (restlessness), 4 mo. tardive dyskinesia (caused by activation of the nigrostriatal pathway)
Low potency neuroleptics
Chlorpromazine (Corneal deposits), Thioridazine (reTinal deposits)
High potency neuroleptics
Haloperidol, trifluoperizine (more neurologic side effects)
Atypical antipsychotics
Block 5HT-2 and D2 receptors
Atypical antipsychotics mneumonic
Its ATYPICAL for OLd CLOZets to QUIETly RISPER from A to Z

(Olanzapine, Clozapine, Quietiapine, Risperidone, Aripiprazole, Ziprasidone)
Side effect of Clozapine
Agranulocytosis (weekly WBC monitoring), seizures
Use of atypical psychotics in schizophrenia
Treat positive and negative symptoms
Lithium MOA
Inhibit phosphoinositol cascade
Lithium side effects
(LMNOP) Movement (tremors), Nephrogenic diabetes insipidus, hypOthyroidism, Pregnancy problems
Buspirone
Stimulates 5HT-1A receptors. Used for anxiety. Not addictive
SSRI MOA
Block reuptake of serotonin
SSRI side effects
Serotonin syndrome with MAO-Is
Serotonin syndrome
Hyperthermia, muscle rigidity, cardiovascular collapse
Tricyclic antidepressants MOA
Block reuptake of NE and serotonin
TCA side effects
Sedation, anticholinergic
Toxicity of TCAs
"tri-C's" Convulsion, Coma, Cardiotoxicity

also hallucination in elderly
Rx: NaHCO3 for CV toxicity
Bupropion
Atypical Antidepressant and for smoking cessation; increased NE and Dopa; no sex SEs
SNRIs
-Venlafaxine, duloxetine
-MOA: inhibits NE > 5HT reuptake
-SE: increase BP
Mirtazapine
Antidepressent. Alpha2 antagonist, 5HT-2 and 5HT-3 antagonist.
Maprotiline
Antidepressant, NE reuptake blocker
Trazodone
- inhibits 5-HT reuptake
- treats insomnia
- SE: priapism "TrazoBONE"
MAO-I's MOA
Increase levels of amine NT's
Side effects of MAO-I's
Hypertensive crisis with Beta blockers and tyramine. Serotonin syndrome with SSRIs or meperidine.
Methylphenidate
Increase release of NE
Panic Disorder
SSRI, TCA, Benzodiazepines
Side effects of Ziprasidone
may prolong QT interval
Clinic use of Lithium
Mood stabilizer, blocks relapse and acute manic events. Also SIADH
Venlafaxine
SNRI - depression and GAD
Duloxetine
SNRI - depression and diabetic peripheral neuropathy