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Neuroleptic malignant syndrome, Extrapyramidal symptoms, galactorhhea; muscarinic alpha and histamine blocking effects
Neuroleptic Malignant syndrome (NMS)
Rigidity, myoglobinuria, ANS instability, pyrexia
"FEVER" - Fever, Encephalopathy, Vitals unstable, Elevated enzymes, Rigidity of muscles
Evolution of Extrapyramidal symptoms
4 h acute dystonia, 4 d akinesia (Parksinsonian Sx), 4 wk akathisia (restlessness), 4 mo. tardive dyskinesia (caused by activation of the nigrostriatal pathway)
Atypical antipsychotics mneumonic
Its ATYPICAL for OLd CLOZets to QUIETly RISPER from A to Z
(Olanzapine, Clozapine, Quietiapine, Risperidone, Aripiprazole, Ziprasidone)
Lithium side effects
(LMNOP) Movement (tremors), Nephrogenic diabetes insipidus, hypOthyroidism, Pregnancy problems
Toxicity of TCAs
"tri-C's" Convulsion, Coma, Cardiotoxicity
also hallucination in elderly
Rx: NaHCO3 for CV toxicity
Side effects of MAO-I's
Hypertensive crisis with Beta blockers and tyramine. Serotonin syndrome with SSRIs or meperidine.
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