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Terms in this set (7)
-IOP > 21 at some point
-glaucomatous ON damage
-characteristic VF loss
-no signs of secondary glaucoma or other types of optic neuropathy
Risk factors for POAG? (7)
-FHx (1st deg relative)
-DM (some correlation)
-myopia (possibly more susceptible to glauc damage)
What are the mutated loci called? name the top 4 susceptible genes (which is #1 most commonly mutated and a/w POAG?).
-GLC1A - GLC10
-susceptible genes: #1 = MYOC (codes for the glycoprotein myocilin - found in TM among other ocular tissues); OPTN (codes for optineurin); WDR36; NTF4
What is the basic pathogenesis of glaucomatous optic neuropathy?
-apoptosis (not necrosis)
-possibly mechanical damage vs ischemic damage...leads to reduced axoplasmic flow...reduced nutrients and removal of metabolic waste
Standard tests in work-up?
-full normal dilated eye exam
-pachymetry for CCT
-optic disc or peripapillary RNFL imaging
Types of VF defects seen in POAG?
-earliest= paracentral 70% of time
-enlarging or deepening scotoma
-central island (end-stage)
What is the main treatment approach?
-IOP reduction (could set a target IOP, or go for a proportional reduction (reduce IOP by __%))
-use meds first, then possibly ALT/SLT, then surgery
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Missed glaucoma questions
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