-widely distributed, but has a poor penetration at the brain at therapeutic doses (causes weak stim)
Where is atropine metabolized and excreted?
-metabolized in the liver -excreted in urine and milk
What is the duration of action for injected atropine?
What is the duration of action for atropine given orally?
What is the duration of action for atropine given topically on the eye?
up to 5 days
What are the therapeutic uses for atropine?
-bradycardia and AV block (incomplete) -mydriatic and cycloplegia -preanesthetic (decreases bronchial and exocrine gland secretions) -organophosphate and other cholinesterase inhibitor poisoning -mushroom (Amanita spp) poisoning
What are the adverse effects of atropine?
-tachycardia (if given IV) -blurred vision, mydriasis, and cycloplegia -nausea, vomiting (is an alkaloid and can irritate oral mucosa), GIT hypomotility (can be used as an antispasmodic) and constipation (ileus) -dry mouth (xerostomia) -dry eye -urinary retention
What are the contraindications/precautions against using atropine?